Alkylated phenanthrene distributions in black rockfish (Sebastes schlegelii) and biotransformation into hydroxylated metabolites after intragastric administration SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Ndabambi, M. | - |
dc.contributor.author | Kim, Ki Yong | - |
dc.contributor.author | Jung, Jee Hyun | - |
dc.contributor.author | Yim, Un Hyuk | - |
dc.contributor.author | Oh, Jeong-Eun | - |
dc.date.accessioned | 2020-12-10T07:56:52Z | - |
dc.date.available | 2020-12-10T07:56:52Z | - |
dc.date.created | 2020-11-09 | - |
dc.date.issued | 2021-03-25 | - |
dc.identifier.issn | 0048-9697 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/38778 | - |
dc.description.abstract | Marine organisms such as fish are at risk of exposure to petrogenic polycyclic aromatic hydrocarbons (PAHs) released in oil spills. PAH toxicities are affected by the rates of PAH biotransformation and elimination in fish tissues, but little information on these rates is available. In this study, the biotransformation and tissue distribution of methylated phenanthrenes-typical petrogenic PAHs found after oil spills-in black rockfish (Sebastes schlegelii) were investigated. Two groups of fish were used. Each fish in one group was given a single intragastric dose of 3-methylphenanthrene, and each fish in the other group was given a single intragastric dose of 3,6-dimethylphenanthrene. The fish were allowed to recover in purified sea water for 196 h. Methylated phenanthreneswere detected in only blood and liver for 24 h after dosing, but the concentrations decreased over time and > 98% had been eliminated by the end of the study. Four mono-hydroxylated metabolites of 3,6-dimethylphenanthrene and six mono-hydroxylated metabolites of 3-methylphenanthrene were tentatively identified for the first time from tandem mass spectrometry analyses of fish bile. The concentrations of these metabolites in bile remained constant for 192 h, suggesting that the metabolites could be used as biomarkers of rockfish exposure to petrogenic PAHs. (C) 2020 Elsevier B.V. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.subject | POLYCYCLIC AROMATIC-HYDROCARBONS | - |
dc.subject | HORIZON OIL-SPILL | - |
dc.subject | HEAVY CRUDE-OIL | - |
dc.subject | HEMATOLOGICAL PARAMETERS | - |
dc.subject | BIOMARKER RESPONSES | - |
dc.subject | TOXICITY | - |
dc.subject | FISH | - |
dc.subject | BIOACCUMULATION | - |
dc.subject | ACTIVATION | - |
dc.subject | PAHS | - |
dc.title | Alkylated phenanthrene distributions in black rockfish (Sebastes schlegelii) and biotransformation into hydroxylated metabolites after intragastric administration | - |
dc.type | Article | - |
dc.citation.title | SCIENCE OF THE TOTAL ENVIRONMENT | - |
dc.citation.volume | 762 | - |
dc.contributor.alternativeName | 정지현 | - |
dc.contributor.alternativeName | 임운혁 | - |
dc.identifier.bibliographicCitation | SCIENCE OF THE TOTAL ENVIRONMENT, v.762 | - |
dc.identifier.doi | 10.1016/j.scitotenv.2020.143160 | - |
dc.identifier.scopusid | 2-s2.0-85094582095 | - |
dc.identifier.wosid | 000607910300083 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | POLYCYCLIC AROMATIC-HYDROCARBONS | - |
dc.subject.keywordPlus | HORIZON OIL-SPILL | - |
dc.subject.keywordPlus | HEAVY CRUDE-OIL | - |
dc.subject.keywordPlus | HEMATOLOGICAL PARAMETERS | - |
dc.subject.keywordPlus | BIOMARKER RESPONSES | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | FISH | - |
dc.subject.keywordPlus | BIOACCUMULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PAHS | - |
dc.subject.keywordAuthor | Methylphenanthrene | - |
dc.subject.keywordAuthor | Hydroxylated methylphenanthrene | - |
dc.subject.keywordAuthor | Cytochrome P450 | - |
dc.subject.keywordAuthor | Biotransformation | - |
dc.subject.keywordAuthor | Biliary metabolites | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |