Triterpene Glycosides Isolated from the Edible Sea Cucumber Bohadschia vitiensis and Their Antagonistic Activity against Transient Receptor Potential Ankyrin 1
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Title
- Triterpene Glycosides Isolated from the Edible Sea Cucumber Bohadschia vitiensis and Their Antagonistic Activity against Transient Receptor Potential Ankyrin 1
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Author(s)
- Choi, Hansol; Oh C.; Hyun J.; Yang J.; Song M.J.; Lee, Hyi Seung; Lee, Yeon Ju
- KIOST Author(s)
- Oh, Chul Hong(오철홍); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주)
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Alternative Author(s)
- 최한솔; 오철홍; 이희승; 이연주
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Publication Year
- 2020-05
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Abstract
- Transient receptor potential ankyrin 1 (TRPA1) is a cation channel that plays a critical role in the occurrence and transmission of pain. By screening 393 marine invertebrate extracts for their antagonistic activity against TRPA1, it was found that the extract of the edible sea cucumber Bohadschia vitiensis had a remarkable potency. Bioassay-guided separation of the extract resulted in the isolation of six triterpene glycosides, including a novel analog. All six isolated compounds exhibited high inhibitory potency against TRPA1 (IC50 values ranging from 0.60 to 3.26 μM), which is comparable to that of a previously developed synthetic antagonist (A-967079). The discovery of TRPA1 antagonists, originated from this edible sea cucumber, opens the door for the elaboration of the valuable triterpene scaffold for the development of novel safe analgesics.
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ISSN
- 0021-8561
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/38675
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DOI
- 10.1021/acs.jafc.0c00847
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Bibliographic Citation
- Journal of Agricultural and Food Chemistry, v.68, no.19, pp.5349 - 5355, 2020
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Publisher
- American Chemical Society
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Keywords
- transient receptor potential ankyrin 1; sea cucumber; Bohadschia vitiensis; triterpene glycoside; pain
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Type
- Article
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Language
- English
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Document Type
- Article
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