Radical Scavenging Activity of Poncirus trifoliata Extracts and Their Inhibitory Effect Against Hydrogen Peroxide Induced Cell Damage
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Title
- Radical Scavenging Activity of Poncirus trifoliata Extracts and Their Inhibitory Effect Against Hydrogen Peroxide Induced Cell Damage
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Author(s)
- Eom, Sung-Hwan; Heo, Soo-Jin; Lee, Dae-Sung; Lee, Myung-Suk; Kim, Young-Man; Jung, Won-Kyo; Kim, Young-Mog
- KIOST Author(s)
- Heo, Soo Jin(허수진)
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Alternative Author(s)
- 허수진
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Publication Year
- 2011-06
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Abstract
- Poncirus trifoliata was evaluated for antioxidant potential by several radical-scavenging assays, including 1,1-diphenyl-2-picrylhydrazyl, superoxide, hydroxyl, and alkyl radicals, using electron spin resonance technique. P trifoliata extracts were prepared by using water and methanol, partitioning with different organic solvents. Among the tested samples, water extract and dichloromethane fraction evidenced relatively higher scavenging activities than those of other samples on reactive radicals and have high amount of antioxidant component such as flavonoids (8.5 +/- 0.3 and 8.3 +/- 0.2 mg rutin equivalents/g dry weight basis) and proanthocyanidin (2.6 +/- 0.3 and 2.8 +/- 0.5 mg catechin equivalents/g dry weight basis), respectively. Moreover, the water extract showed significantly high enhancement of cell viability against hydrogen peroxide-induced oxidative damage as well as reduction in the hydrogen peroxide-induced intracellular reactive oxygen species on CCL. 13 cell line. These results indicate that P trifoliate exerts various antioxidant effects against several reactive radicals and hydrogen peroxide-mediated cell damage. Thus, P trifoliate could be a potential therapeutic modality for the treatment or prevention of several diseases associated with oxidative stress.
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ISSN
- 1738-2203
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3860
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DOI
- 10.3839/jksabc.2011.074
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Bibliographic Citation
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.54, no.3, pp.479 - 487, 2011
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Publisher
- KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
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Subject
- ANTIOXIDANT ACTIVITY; ENZYMATIC EXTRACTS; SUPEROXIDE; APOPTOSIS; GROWTH; FRUIT; ASSAY; CATECHINS; CAPACITY; NECROSIS
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Keywords
- antioxidant; cell damage; electron spin resonance; Poncirus trifoliata; radical scavenging
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Type
- Article
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Language
- English
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Document Type
- Article
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