Radical Scavenging Activity of Poncirus trifoliata Extracts and Their Inhibitory Effect Against Hydrogen Peroxide Induced Cell Damage SCIE SCOPUS KCI

Cited 2 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
Radical Scavenging Activity of Poncirus trifoliata Extracts and Their Inhibitory Effect Against Hydrogen Peroxide Induced Cell Damage
Author(s)
Eom, Sung-Hwan; Heo, Soo-Jin; Lee, Dae-Sung; Lee, Myung-Suk; Kim, Young-Man; Jung, Won-Kyo; Kim, Young-Mog
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2011-06
Abstract
Poncirus trifoliata was evaluated for antioxidant potential by several radical-scavenging assays, including 1,1-diphenyl-2-picrylhydrazyl, superoxide, hydroxyl, and alkyl radicals, using electron spin resonance technique. P trifoliata extracts were prepared by using water and methanol, partitioning with different organic solvents. Among the tested samples, water extract and dichloromethane fraction evidenced relatively higher scavenging activities than those of other samples on reactive radicals and have high amount of antioxidant component such as flavonoids (8.5 +/- 0.3 and 8.3 +/- 0.2 mg rutin equivalents/g dry weight basis) and proanthocyanidin (2.6 +/- 0.3 and 2.8 +/- 0.5 mg catechin equivalents/g dry weight basis), respectively. Moreover, the water extract showed significantly high enhancement of cell viability against hydrogen peroxide-induced oxidative damage as well as reduction in the hydrogen peroxide-induced intracellular reactive oxygen species on CCL. 13 cell line. These results indicate that P trifoliate exerts various antioxidant effects against several reactive radicals and hydrogen peroxide-mediated cell damage. Thus, P trifoliate could be a potential therapeutic modality for the treatment or prevention of several diseases associated with oxidative stress.
ISSN
1738-2203
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3860
DOI
10.3839/jksabc.2011.074
Bibliographic Citation
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.54, no.3, pp.479 - 487, 2011
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Subject
ANTIOXIDANT ACTIVITY; ENZYMATIC EXTRACTS; SUPEROXIDE; APOPTOSIS; GROWTH; FRUIT; ASSAY; CATECHINS; CAPACITY; NECROSIS
Keywords
antioxidant; cell damage; electron spin resonance; Poncirus trifoliata; radical scavenging
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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