Formation and distribution of phenanthrene and its metabolites (monohydroxy-phenanthrenes) in Korean rockfish (Sebastes schlegelii) SCIE SCOPUS

Cited 2 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
Formation and distribution of phenanthrene and its metabolites (monohydroxy-phenanthrenes) in Korean rockfish (Sebastes schlegelii)
Author(s)
Ekpe O.D.; Kim K.Y.; Jung J.-H.; Yim U.-H.; Oh J.-E.
KIOST Author(s)
Jung, Jee Hyun(정지현)Yim, Un Hyuk(임운혁)
Publication Year
2020-08
Abstract
This study investigated the tissue distribution of phenanthrene (PHE) and the formation of monohydroxy-phenanthrene (OH-PHE) metabolites in Korean rockfish (Sebastes schlegelii). PHE was intragastrically administered to two groups of rockfish. The first group was exposed to PHE at a low dose (10 mg/kg body weight) and the second group was exposed at a high dose (30 mg/kg body weight). The rockfish were analyzed and the levels of PHE were higher in the liver, followed by muscle, and then bile. PHE concentrations in the liver, muscle, and bile were 1.4-26, 0.10-2.01, and not detected (ND)-0.13 mu g/g wet weight, respectively. All five monohydroxylated PHE metabolites (1-OH-PHE, 2-OH-PHE, 3-OH-PHE, 4-OH-PHE, and 9-OH-PHE) were detected only in bile. Among these OH-PHE metabolites, 3-OH-PHE was found at the highest concentration from all fish bile samples in both PHE exposure groups, indicating that regioselective OH-PHE formation occurs in rockfish and 3-OH PHE could be a good biomarker of exposure of Korean rockfish to PHE. Suspect screening analysis of the rockfish bile was performed by LC-QTOF/MS, and the formation of two OH-PHE-DNA adducts (thymine-OH-PHE and cytosine-OH-PHE) were identified in the bile sample collected 6 h after rockfish were exposed to the high PHE dose, indicating that OH-PHE metabolites may be toxic to fish. This is the first report on the formation characteristics of OH-PHE metabolites in rockfish and their use as biomarkers of exposure of rockfish to parent PHE. (c) 2020 Elsevier Ltd. All rights reserved.
ISSN
0269-7491
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/38594
DOI
10.1016/j.envpol.2020.114588
Bibliographic Citation
ENVIRONMENTAL POLLUTION, v.263, 2020
Publisher
ELSEVIER SCI LTD
Keywords
Phenanthrene; Monohydroxy-phenanthrene; Tissue distribution; Regioselective formation; Biomarker
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCI LTD
Related Researcher
Research Interests

Oil Spill Environmental Forensics,Persistent Organic Pollutants,Marine Aerosol,유류오염 환경법과학,지속성유기오염물질,해양 에어로졸

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