Formation and distribution of phenanthrene and its metabolites (monohydroxy-phenanthrenes) in Korean rockfish (Sebastes schlegelii) SCIE SCOPUS

DC Field Value Language
dc.contributor.author Ekpe O.D. -
dc.contributor.author Kim K.Y. -
dc.contributor.author Jung J.-H. -
dc.contributor.author Yim U.-H. -
dc.contributor.author Oh J.-E. -
dc.date.accessioned 2020-12-10T07:46:53Z -
dc.date.available 2020-12-10T07:46:53Z -
dc.date.created 2020-05-27 -
dc.date.issued 2020-08 -
dc.identifier.issn 0269-7491 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/38594 -
dc.description.abstract This study investigated the tissue distribution of phenanthrene (PHE) and the formation of monohydroxy-phenanthrene (OH-PHE) metabolites in Korean rockfish (Sebastes schlegelii). PHE was intragastrically administered to two groups of rockfish. The first group was exposed to PHE at a low dose (10 mg/kg body weight) and the second group was exposed at a high dose (30 mg/kg body weight). The rockfish were analyzed and the levels of PHE were higher in the liver, followed by muscle, and then bile. PHE concentrations in the liver, muscle, and bile were 1.4-26, 0.10-2.01, and not detected (ND)-0.13 mu g/g wet weight, respectively. All five monohydroxylated PHE metabolites (1-OH-PHE, 2-OH-PHE, 3-OH-PHE, 4-OH-PHE, and 9-OH-PHE) were detected only in bile. Among these OH-PHE metabolites, 3-OH-PHE was found at the highest concentration from all fish bile samples in both PHE exposure groups, indicating that regioselective OH-PHE formation occurs in rockfish and 3-OH PHE could be a good biomarker of exposure of Korean rockfish to PHE. Suspect screening analysis of the rockfish bile was performed by LC-QTOF/MS, and the formation of two OH-PHE-DNA adducts (thymine-OH-PHE and cytosine-OH-PHE) were identified in the bile sample collected 6 h after rockfish were exposed to the high PHE dose, indicating that OH-PHE metabolites may be toxic to fish. This is the first report on the formation characteristics of OH-PHE metabolites in rockfish and their use as biomarkers of exposure of rockfish to parent PHE. (c) 2020 Elsevier Ltd. All rights reserved. -
dc.description.uri 1 -
dc.language English -
dc.publisher ELSEVIER SCI LTD -
dc.title Formation and distribution of phenanthrene and its metabolites (monohydroxy-phenanthrenes) in Korean rockfish (Sebastes schlegelii) -
dc.type Article -
dc.citation.title ENVIRONMENTAL POLLUTION -
dc.citation.volume 263 -
dc.contributor.alternativeName 정지현 -
dc.contributor.alternativeName 임운혁 -
dc.identifier.bibliographicCitation ENVIRONMENTAL POLLUTION, v.263 -
dc.identifier.doi 10.1016/j.envpol.2020.114588 -
dc.identifier.scopusid 2-s2.0-85083786980 -
dc.identifier.wosid 000539426400124 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordPlus POLYCYCLIC AROMATIC-HYDROCARBONS -
dc.subject.keywordPlus EELS ANGUILLA-ANGUILLA -
dc.subject.keywordPlus FISH BILE -
dc.subject.keywordPlus HYDROXYLATED METABOLITES -
dc.subject.keywordPlus BACTERIAL-DEGRADATION -
dc.subject.keywordPlus PAH METABOLITES -
dc.subject.keywordPlus BILIARY METABOLITES -
dc.subject.keywordPlus DNA-ADDUCTS -
dc.subject.keywordPlus BIOTRANSFORMATION -
dc.subject.keywordPlus BIOACCUMULATION -
dc.subject.keywordAuthor Phenanthrene -
dc.subject.keywordAuthor Monohydroxy-phenanthrene -
dc.subject.keywordAuthor Tissue distribution -
dc.subject.keywordAuthor Regioselective formation -
dc.subject.keywordAuthor Biomarker -
dc.relation.journalWebOfScienceCategory Environmental Sciences -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Environmental Sciences & Ecology -
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