5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice SCIE SCOPUS

Cited 1 time in WEB OF SCIENCE Cited 0 time in Scopus
Title
5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice
Author(s)
Han E.J.; Fernando I.P.S.; Kim E.-A.; Kim J.; Jung K.; Kim S.-Y.; Cha S.-H.; Kim K.-N.; Heo S.-J.; Ahn G.
KIOST Author(s)
Kim, Eun A(김은아)Kim, Junseong(김준성)Heo, Soo Jin(허수진)
Publication Year
2020-08
Abstract
The present study investigates the anti-allergic activity of the marine algal bromophenol, 3-bromo-4,5-dihy-droxybenzaldehyde (BDB), isolated from Polysiphonia morrowii Harvey in immunoglobulin (Ig)E/bovine serum albumin (BSA)-stimulated mouse bone marrow-derived cultured mast cells (BMCMCs) and a passive cutaneous anaphylaxis (PCA) mice ear model. BDB effectively inhibited beta-hexosaminidase release (IC50 = 80.12 mu M), in IgE/BSA-stimulated BMCMCs without a cytotoxic response. Also, BDB down-regulated the expression or secretion of cytokines, interleukin (IL)-1 beta, IL-4, IL-5, IL-6, IL-10, IL-13, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and the chemokine (thymus and activation-regulated chemokine (TARC). The above effects could be attributed to the dose-dependent decrease of Fc epsilon RI expression on the surface of BMCMCs and its stable IgE binding. Moreover, BDB suppressed the nuclear factor (NF)-kappa B and spleen tyrosine kinase (SYK)-linker for T-cell activation (LAT)-GRB2 associated binding protein 2 (Gab2) signaling axis activated by IgE/BSA stimulation. Furthermore, oral administration of BDB to IgE-sensitized mice effectively attenuated IgE-triggered PCA reaction. Collectively, the anti-allergic effects of BDB suggest its potential applicability as a candidate for in-depth test trials.
ISSN
0006-2952
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/38592
DOI
10.1016/j.bcp.2020.114087
Bibliographic Citation
BIOCHEMICAL PHARMACOLOGY, v.178, 2020
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
5-Bromo-3,4-dihydroxybenzaldehyde; Anti-allergic; Mast cells, Immunoglobulin E; Passive cutaneous anaphylaxis
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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