5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Han E.J. | - |
dc.contributor.author | Fernando I.P.S. | - |
dc.contributor.author | Kim E.-A. | - |
dc.contributor.author | Kim J. | - |
dc.contributor.author | Jung K. | - |
dc.contributor.author | Kim S.-Y. | - |
dc.contributor.author | Cha S.-H. | - |
dc.contributor.author | Kim K.-N. | - |
dc.contributor.author | Heo S.-J. | - |
dc.contributor.author | Ahn G. | - |
dc.date.accessioned | 2020-12-10T07:46:47Z | - |
dc.date.available | 2020-12-10T07:46:47Z | - |
dc.date.created | 2020-06-29 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/38592 | - |
dc.description.abstract | The present study investigates the anti-allergic activity of the marine algal bromophenol, 3-bromo-4,5-dihy-droxybenzaldehyde (BDB), isolated from Polysiphonia morrowii Harvey in immunoglobulin (Ig)E/bovine serum albumin (BSA)-stimulated mouse bone marrow-derived cultured mast cells (BMCMCs) and a passive cutaneous anaphylaxis (PCA) mice ear model. BDB effectively inhibited beta-hexosaminidase release (IC50 = 80.12 mu M), in IgE/BSA-stimulated BMCMCs without a cytotoxic response. Also, BDB down-regulated the expression or secretion of cytokines, interleukin (IL)-1 beta, IL-4, IL-5, IL-6, IL-10, IL-13, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha and the chemokine (thymus and activation-regulated chemokine (TARC). The above effects could be attributed to the dose-dependent decrease of Fc epsilon RI expression on the surface of BMCMCs and its stable IgE binding. Moreover, BDB suppressed the nuclear factor (NF)-kappa B and spleen tyrosine kinase (SYK)-linker for T-cell activation (LAT)-GRB2 associated binding protein 2 (Gab2) signaling axis activated by IgE/BSA stimulation. Furthermore, oral administration of BDB to IgE-sensitized mice effectively attenuated IgE-triggered PCA reaction. Collectively, the anti-allergic effects of BDB suggest its potential applicability as a candidate for in-depth test trials. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | 5-Bromo-3,4-dihydroxybenzaldehyde from Polysiphonia morrowii attenuate IgE/BSA-stimulated mast cell activation and passive cutaneous anaphylaxis in mice | - |
dc.type | Article | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 178 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.contributor.alternativeName | 김준성 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.178 | - |
dc.identifier.doi | 10.1016/j.bcp.2020.114087 | - |
dc.identifier.scopusid | 2-s2.0-85086603396 | - |
dc.identifier.wosid | 000551658300033 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | MARINE-ALGAE | - |
dc.subject.keywordPlus | IGE | - |
dc.subject.keywordPlus | BROMOPHENOL | - |
dc.subject.keywordAuthor | 5-Bromo-3,4-dihydroxybenzaldehyde | - |
dc.subject.keywordAuthor | Anti-allergic | - |
dc.subject.keywordAuthor | Mast cells, Immunoglobulin E | - |
dc.subject.keywordAuthor | Passive cutaneous anaphylaxis | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |