Monanchocidins B-E: Polycyclic Guanidine Alkaloids with Potent Antileukemic Activities from the Sponge Monanchora pulchra SCIE SCOPUS
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- Title
- Monanchocidins B-E: Polycyclic Guanidine Alkaloids with Potent Antileukemic Activities from the Sponge Monanchora pulchra
- KIOST Author(s)
- Lee, Hyi Seung(이희승)
- Alternative Author(s)
- 이희승
- Publication Year
- 2011-09
- Abstract
- New unusual polycyclic guanidine alkaloids monanchocidins B-E (2-5) along with monanchocidin A (1), which we recently described, were isolated from the Far-Eastern marine sponge Monanchora pulchra. Their structures were established using spectroscopic data and chemical transformations. Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells with IC(50) values of 540, 200, 110, 830, and 650 nM, respectively.
- ISSN
- 0163-3864
- Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.74, no.9, pp.1952 - 1958, 2011
- Publisher
- AMER CHEMICAL SOC
- Subject
- CRAMBE-CRAMBE; PTILOMYCALIN-A; BATZELLA SP; UNGUIFERA; CRAMBESCIDIN-800; DERIVATIVES; HIV-1
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
