Monanchocidins B-E: Polycyclic Guanidine Alkaloids with Potent Antileukemic Activities from the Sponge Monanchora pulchra SCIE SCOPUS

Cited 53 time in WEB OF SCIENCE Cited 51 time in Scopus
Title
Monanchocidins B-E: Polycyclic Guanidine Alkaloids with Potent Antileukemic Activities from the Sponge Monanchora pulchra
Author(s)
Makarieva, Tatyana N.; Tabakmaher, Ksenya M.; Guzii, Alla G.; Denisenko, Vladimir A.; Dmitrenok, Pavel S.; Shubina, Larisa K.; Kuzmich, Alexandra S.; Lee, Hyi-Seung; Stonik, Valentin A.
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2011-09
Abstract
New unusual polycyclic guanidine alkaloids monanchocidins B-E (2-5) along with monanchocidin A (1), which we recently described, were isolated from the Far-Eastern marine sponge Monanchora pulchra. Their structures were established using spectroscopic data and chemical transformations. Compounds 1-5 show potent cytotoxic activities against HL-60 human leukemia cells with IC(50) values of 540, 200, 110, 830, and 650 nM, respectively.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3818
DOI
10.1021/np200452m
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.74, no.9, pp.1952 - 1958, 2011
Publisher
AMER CHEMICAL SOC
Subject
CRAMBE-CRAMBE; PTILOMYCALIN-A; BATZELLA SP; UNGUIFERA; CRAMBESCIDIN-800; DERIVATIVES; HIV-1
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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