Anti-Neuroinflammatory Agent, Restricticin B, from the Marine-Derived Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells SCIE SCOPUS

Cited 6 time in WEB OF SCIENCE Cited 5 time in Scopus
Title
Anti-Neuroinflammatory Agent, Restricticin B, from the Marine-Derived Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells
Author(s)
Choi, Byeoung Kyu; Jo, Song-Hee; Choi, Dong-Kug; Trinh, Phan Thi Hoai; Lee, Hwa Sun; ANH, CAO VAN; Van, Tran Thi Thanh; Shin, Hee Jae
KIOST Author(s)
Lee, Hwa Sun(이화선)ANH, CAO VAN(Cao Van Anh)Shin, Hee Jae(신희재)
Publication Year
2020-09
Abstract
A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D and 2D NMR data. The relative and absolute configurations of 1 were established via the analyses of NOESY spectroscopy data, the comparison of optical rotation values with those of reported restricticin derivatives and electronic circular dichroism (ECD). All the compounds were screened for their anti-neuroinflammatory effects in lipopolysaccharide (LPS)-induced BV-2 microglia cells. Restricticin B (1) and N-acetyl restricticin (2) exhibited anti-neuroinflammatory effects by suppressing the production of pro-inflammatory mediators in activated microglial cells.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/37599
DOI
10.3390/md18090465
Bibliographic Citation
MARINE DRUGS, v.18, no.9, 2020
Publisher
MDPI
Subject
LANOSTEROL C-14 DEMETHYLASE; NATURAL ANTIFUNGALS; SERIES
Keywords
restricticin; marine-derived fungus; Penicillium janthinellum; BV-2 microglia cells; anti-neuroinflammatory
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
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