Isolation and identification of new compound, 2,7 ''-phloroglucinol-6,6 '-bieckol from brown algae, Ecklonia cava and its antioxidant effect SCIE SCOPUS

Cited 41 time in WEB OF SCIENCE Cited 47 time in Scopus
Title
Isolation and identification of new compound, 2,7 ''-phloroglucinol-6,6 '-bieckol from brown algae, Ecklonia cava and its antioxidant effect
Author(s)
Kang, Sung-Myung; Heo, Soo-Jin; Kim, Kil-Nam; Lee, Seung-Hong; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2012-01
Abstract
Brown algae, Ecklonia cava has been regarded as a useful material in the prevention or treatment of several human diseases in Jeju Island, Korea. In this study, we investigated its antioxidant activity, and isolated a new antioxidative compound, which was identified as 2,7"-phloroglucino1-6,6'-bieckol (PHB) on the basis of LC/MS, as well as H-1 and C-13 NMR spectroscopy results. The antioxidant activity of PHB was evaluated via several in vitro assays, such as radical scavenging activities using electron spin resonance spectrometry, intracellular reactive oxygen species scavenging activity, and DNA damage assays. PHB evidenced profound scavenging activities on DPPH, alkyl, hydroxyl, and superoxide radicals (IC50: 0.51, 2.07, 75.64 and 57.19 mu M for DPPH, alkyl, hydroxyl and superoxide radicals, respectively). The antioxidant activity of PHB was higher than that of ascorbic acid. Furthermore, PHB effectively inhibited H2O2-induced DNA damage. The results of this study indicate that PHB may prove useful as a novel natural marine antioxidant. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN
1756-4646
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3699
DOI
10.1016/j.jff.2011.10.001
Bibliographic Citation
JOURNAL OF FUNCTIONAL FOODS, v.4, no.1, pp.158 - 166, 2012
Publisher
ELSEVIER SCIENCE BV
Subject
INDUCED CELL-DAMAGE; TEA CATECHINS; PHLOROTANNINS; PHLOROGLUCINOL; RADICALS; ESR
Keywords
Ecklonia cava; 2,7 ' ' -Phloroglucinol-6,6 ' -bieckol; Antioxidant
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE BV
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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