Biosynthesis of lactate-containing polyesters by metabolically engineered bacteria SCIE SCOPUS

Cited 25 time in WEB OF SCIENCE Cited 0 time in Scopus
Title
Biosynthesis of lactate-containing polyesters by metabolically engineered bacteria
Author(s)
Park, Si Jae; Lee, Sang Yup; Kim, Tae Wan; Jung, Yu Kyung; Yang, Taek Ho
Publication Year
2012-02
Abstract
Due to increasing concerns about environmental problems, climate change and limited fossil resources, bio-based production of chemicals and polymers is gaining attention as one of the solutions to these problems. Polyhydroxyalkanoates (PHAs) are polyesters that can be produced by microbial fermentation. PHAs are synthesized using monomer precursors provided from diverse metabolic pathways and are accumulated as distinct granules inside the cells. On the other hand, most so-called bio-based polymers including polybutylene succinate, polytrimethylene tereph-thalate, and polylactic acid (PLA) are synthesized by a chemical process using monomers produced by fermentation. PLA, an attractive biomass-derived plastic, is currently synthesized by heavy metal-catalyzed ring opening polymerization of L-lactide that is made from fermentation-derived L-lactic acid. Recently, a complete biological process for the production of PLA and PLA copolymers from renewable resources has been developed by direct fermentation of recombinant bacteria employing PHA biosynthetic pathways coupled with a novel metabolic pathway. This could be accomplished by establishing a pathway for generating lactyl-CoA and engineering PHA synthase to accept lactyl-CoA as a substrate combined with systems metabolic engineering. In this article, we review recent advances in the production of lactate-containing homo-and co-polyesters. Challenges remaining to efficiently produce PLA and its copolymers and strategies to overcome these challenges through metabolic engineering combined with enzyme engineering are discussed.
ISSN
1860-6768
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3629
DOI
10.1002/biot.201100070
Bibliographic Citation
BIOTECHNOLOGY JOURNAL, v.7, no.2, pp.199 - 212, 2012
Publisher
WILEY-V C H VERLAG GMBH
Subject
POLYHYDROXYALKANOATE PHA SYNTHASE; PROPIONATE COA-TRANSFERASE; ESCHERICHIA-COLI; POLYLACTIC ACID; MOLECULAR-WEIGHT; LACTIC-ACID; IN-VIVO; POLY(3-HYDROXYBUTYRATE); COPOLYMERS; ENZYME
Keywords
Lactyl-CoA; Polyhydroxyalkanoate; Polyhydroxyalkanoate synthase; Polylactic acid; Polylactic acid copolymer
Type
Article
Language
English
Document Type
Review
Publisher
WILEY-V C H VERLAG GMBH
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