Neuroprotective Effects of Nannochloropsis oculata Against AAPH-induced Oxidative DNA Damage in HT22 Cells SCIE SCOPUS

Cited 2 time in WEB OF SCIENCE Cited 4 time in Scopus
Title
Neuroprotective Effects of Nannochloropsis oculata Against AAPH-induced Oxidative DNA Damage in HT22 Cells
Author(s)
Kim, Kil-Nam; Cha, Seon-Heui; Kim, Eun-A; Kang, Min-Cheol; Yang, Hye-Mi; Kim, Min-Joo; Yang, Hye-Young; Roh, Seong Woon; Jung, Won-Kyo; Heo, Soo-Jin; Kim, Daekyung; Jeon, You-Jin; Oda, Tatsuya
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2012-08-15
Abstract
Water extracts of Nannochloropsis oculata (WNO) were investigated to determine whether they exhibited neuroprotective effects against oxidative-stress-induced cell damage by 2,2'-Azobis (2-amidinopropane) dihydrochloride (AAPH) in murine hippocampus neuronal (HT22) cells. We observed that WNO exhibited scavenging effects on hydroxyl and alkyl radicals as well as on intracellular Reactive Oxygen Species (ROS). As a consequence, WNO reduced AAPH-induced cell death, the fraction of sub-G(1) cells and DNA damage in HT22 cells. The results of this study demonstrate that WNO could be used as an alternative to more toxic synthetic antioxidants as an additive in food, pharmaceutical and cosmetic preparations.
ISSN
1811-7775
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3478
DOI
10.3923/ijp.2012.527.534
Bibliographic Citation
INTERNATIONAL JOURNAL OF PHARMACOLOGY, v.8, no.6, pp.527 - 534, 2012
Publisher
ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET
Subject
MICROALGAE NAVICULA-INCERTA; ANTIOXIDANT ACTIVITIES; ENZYMATIC EXTRACTS; ISHIGE OKAMURAE; ECKLONIA-CAVA; STRESS; TOXICITY; ACID; INDUCTION; RELEVANCE
Keywords
Neuroprotection; water extract; Nannochloprosis oculata; oxidative stress; HT22 cells
Type
Article
Language
English
Document Type
Article
Publisher
ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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