Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells
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Title
- Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells
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Author(s)
- Yoon, Weon-Jong; Heo, Soo-Jin; Han, Sang-Chul; Lee, Hye-Ja; Kang, Gyeoung-Jin; Yang, Eun-Jin; Park, Sun-Soon; Kang, Hee-Kyoung; Yoo, Eun-Sook
- KIOST Author(s)
- Heo, Soo Jin(허수진)
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Alternative Author(s)
- 허수진
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Publication Year
- 2012-09
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Abstract
- Bone diseases are characterized by the presence of pro-inflammatory cytokines that regulate bone turnover. The receptor activator of NF-kappa B ligand (RANKL) is a soluble osteoblast-derived protein that induces bone resorption through osteoclast differentiation and activation. Sargachromanol G (SG) was isolated from the brown algae Sargassum siliquastrum; SG has anti-osteoclastogenic activity, but its mechanism of action and its active components remain largely unknown. In the present study, we investigated the anti-osteoclastogenic effects of SG on the expression of interleukin-1 beta (IL-1 beta)-induced osteoclastogenic factors (PGE(2), COX-2, IL-6, OPG, and RANKL) in the human osteoblast cell line MG-63. We also examined the role of the nuclear factor-kappa B (NF-kappa B) and the mitogen-activated protein kinase (MAPK) signaling pathways in IL-1 beta-stimulated MG-63 cells. SG dose-dependently inhibited the production of osteoclastogenic factors in MG-63 cells. SG also inhibited phosphorylation of MAPK (ERK1/2, p38, and JNK) and NF-kappa B (p65, p50, and I kappa B-alpha). These results suggest that the anti-osteoporotic effect of SG may be because of the modulation of osteoclastogenic factors via suppression of MAPK and NF-kappa B activation. (C) 2012 Elsevier Ltd. All rights reserved.
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ISSN
- 0278-6915
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3472
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DOI
- 10.1016/j.fct.2012.06.022
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Bibliographic Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.50, no.9, pp.3273 - 3279, 2012
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Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
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Subject
- ACTIVATED PROTEIN-KINASE; RAW 264.7 MACROPHAGES; INHIBITS OSTEOCLASTOGENESIS; DEFECTIVE INTERLEUKIN-1; BONE-RESORPTION; IN-VITRO; OSTEOPROTEGERIN; OSTEOPETROSIS; ARTHRITIS; CYTOKINE
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Keywords
- RANKL; Sargachromanol G; Osteoclastogenic factor; MAPK; NF-kappa B
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Type
- Article
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Language
- English
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Document Type
- Article
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