Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Yoon, Weon-Jong | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Han, Sang-Chul | - |
dc.contributor.author | Lee, Hye-Ja | - |
dc.contributor.author | Kang, Gyeoung-Jin | - |
dc.contributor.author | Yang, Eun-Jin | - |
dc.contributor.author | Park, Sun-Soon | - |
dc.contributor.author | Kang, Hee-Kyoung | - |
dc.contributor.author | Yoo, Eun-Sook | - |
dc.date.accessioned | 2020-04-20T06:40:45Z | - |
dc.date.available | 2020-04-20T06:40:45Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/3472 | - |
dc.description.abstract | Bone diseases are characterized by the presence of pro-inflammatory cytokines that regulate bone turnover. The receptor activator of NF-kappa B ligand (RANKL) is a soluble osteoblast-derived protein that induces bone resorption through osteoclast differentiation and activation. Sargachromanol G (SG) was isolated from the brown algae Sargassum siliquastrum; SG has anti-osteoclastogenic activity, but its mechanism of action and its active components remain largely unknown. In the present study, we investigated the anti-osteoclastogenic effects of SG on the expression of interleukin-1 beta (IL-1 beta)-induced osteoclastogenic factors (PGE(2), COX-2, IL-6, OPG, and RANKL) in the human osteoblast cell line MG-63. We also examined the role of the nuclear factor-kappa B (NF-kappa B) and the mitogen-activated protein kinase (MAPK) signaling pathways in IL-1 beta-stimulated MG-63 cells. SG dose-dependently inhibited the production of osteoclastogenic factors in MG-63 cells. SG also inhibited phosphorylation of MAPK (ERK1/2, p38, and JNK) and NF-kappa B (p65, p50, and I kappa B-alpha). These results suggest that the anti-osteoporotic effect of SG may be because of the modulation of osteoclastogenic factors via suppression of MAPK and NF-kappa B activation. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | RAW 264.7 MACROPHAGES | - |
dc.subject | INHIBITS OSTEOCLASTOGENESIS | - |
dc.subject | DEFECTIVE INTERLEUKIN-1 | - |
dc.subject | BONE-RESORPTION | - |
dc.subject | IN-VITRO | - |
dc.subject | OSTEOPROTEGERIN | - |
dc.subject | OSTEOPETROSIS | - |
dc.subject | ARTHRITIS | - |
dc.subject | CYTOKINE | - |
dc.title | Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells | - |
dc.type | Article | - |
dc.citation.endPage | 3279 | - |
dc.citation.startPage | 3273 | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 50 | - |
dc.citation.number | 9 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.50, no.9, pp.3273 - 3279 | - |
dc.identifier.doi | 10.1016/j.fct.2012.06.022 | - |
dc.identifier.scopusid | 2-s2.0-84864135886 | - |
dc.identifier.wosid | 000308624500043 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | RAW 264.7 MACROPHAGES | - |
dc.subject.keywordPlus | INHIBITS OSTEOCLASTOGENESIS | - |
dc.subject.keywordPlus | DEFECTIVE INTERLEUKIN-1 | - |
dc.subject.keywordPlus | BONE-RESORPTION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | OSTEOPROTEGERIN | - |
dc.subject.keywordPlus | OSTEOPETROSIS | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordAuthor | RANKL | - |
dc.subject.keywordAuthor | Sargachromanol G | - |
dc.subject.keywordAuthor | Osteoclastogenic factor | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |