독성 와편모조류 Alexandrium minutum이 해수산 요각류 Tigriopus japonicus에서 해독 관련 유전자의 발현에 미치는 영향

Title
독성 와편모조류 Alexandrium minutum이 해수산 요각류 Tigriopus japonicus에서 해독 관련 유전자의 발현에 미치는 영향
Alternative Title
Effects of toxic dinoflagellate Alexandrium minutum on the expression of detoxification-related genes in the marine copepod Tigriopus japonicus
Author(s)
Han, Jeonghoon; Park, Joon Sang; Lee, Jihoon; Park, Yeun; Shin, Hyeon Ho; Lee, Kyun Woo
KIOST Author(s)
Han, Jeong Hoon(한정훈)Park, Joon Sang(박준상)Lee, Ji Hoon(이지훈)Park, Ye Un(박예은)Shin, Hyeon Ho(신현호)Lee, Kyun Woo(이균우)
Publication Year
2020-07-24
Abstract
To understand the effects of the toxic dinoflagellate Alexandrium minutum on the marine copepod Tigriopus japonicus, we assessed acute toxicity and swimming behavior (swimming speed, swimming distance, and swimming path trajectory) in response to A. minutum exposure. No significant changes in survival and swimming behavior were observed in response to A. minutum. Therefore, to validate the effects of A. minutum on the molecular defense response of T. japonicus, we measured mRNA expression levels of detoxification-related genes (phase I cytochrome P450s [CYPs], and phase II glutathione-S transferases [GSTs]) in response to A. minutum. The mRNA expression levels of these detoxification-related genes (CYPs and GSTs) were significantly up-regulated and down-regulated (P < 0.05) in response to A. minutum. In particular, CYP3024A2 and GST-Theta3 showed significant up-regulation. Overall, these results suggest that CYP and GST genes are likely to play crucial roles in detoxification mechanisms in T. japonicus, resulting in no significant changes in the survival and swimming behavior of this marine copepod in response to A. minutum exposure.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/32903
Bibliographic Citation
2020 한국산학기술학회 춘계학술대회, pp.746, 2020
Publisher
(사)한국산학기술학회, 제주대학교
Type
Conference
Language
Korean
Publisher
(사)한국산학기술학회, 제주대학교
Related Researcher
Research Interests

Marine biology,Environmental toxicology,Molecular biology,해양생물학,환경독성학,분자생물학

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