Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells
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Title
- Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells
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Author(s)
- Kim, Kil-Nam; Ahn, Ginnae; Heo, Soo-Jin; Kang, Sung-Myung; Kang, Min-Cheol; Yang, Hye-Mi; Kim, Daekyung; Roh, Seong Woon; Kim, Se-Kwon; Jeon, Byong-Tae; Park, Pyo-Jam; Jung, Won-Kyo; Jeon, You-Jin
- KIOST Author(s)
- Heo, Soo Jin(허수진)
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Alternative Author(s)
- 허수진
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Publication Year
- 2013-01
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Abstract
- The present study was designed to evaluate the molecular mechanisms of fucoxanthin against melanoma cell lines (B16F10 cells). Fucoxanthin reduced the proliferation of B16F10 cells in a dose-dependent manner accompanied by the induction of cell cycle arrest during the G(0)/G(1) phase and apoptosis. Fucoxanthin-induced G(0)/G(1) arrest was associated with a marked decrease in the protein expressions of phosphorylated-Rb (retinoblastoma protein), cyclin D (1 and 2) and cyclin-dependent kinase (CDK) 4 and up-regulation of the protein levels of p15(INK4B) and p27(KiP1). Fucoxanthin-induced apoptosis was accompanied with the down-regulation of the protein levels of Bcl-xL, an inhibitor of apoptosis proteins (IAPs), resulting in a sequential activation of caspase-9, caspase-3, and PARP. Furthermore, the anti-tumor effect of fucoxanthin was assessed in vivo in Balb/c mice. Intraperitoneal administration of fucoxanthin significantly inhibited the growth of tumor mass in B16F10 cells implanted mice. (C) 2012 Elsevier B.V. All rights reserved.
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ISSN
- 1382-6689
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3279
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DOI
- 10.1016/j.etap.2012.10.002
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Bibliographic Citation
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.35, no.1, pp.39 - 46, 2013
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Publisher
- ELSEVIER
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Subject
- CYCLE ARREST; CDK INHIBITORS; APOPTOSIS; INDUCTION; CANCER; PROTEIN; PROLIFERATION; ACTIVATION; MECHANISMS; EXPRESSION
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Keywords
- Fucoxanthin; Melanoma cell lines (B16F10 cells); Cell arrest; Apoptosis; p27(Kip1); Bcl-xL
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Type
- Article
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Language
- English
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Document Type
- Article
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