Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells SCIE SCOPUS

Cited 59 time in WEB OF SCIENCE Cited 64 time in Scopus
Title
Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells
Author(s)
Kim, Kil-Nam; Ahn, Ginnae; Heo, Soo-Jin; Kang, Sung-Myung; Kang, Min-Cheol; Yang, Hye-Mi; Kim, Daekyung; Roh, Seong Woon; Kim, Se-Kwon; Jeon, Byong-Tae; Park, Pyo-Jam; Jung, Won-Kyo; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2013-01
Abstract
The present study was designed to evaluate the molecular mechanisms of fucoxanthin against melanoma cell lines (B16F10 cells). Fucoxanthin reduced the proliferation of B16F10 cells in a dose-dependent manner accompanied by the induction of cell cycle arrest during the G(0)/G(1) phase and apoptosis. Fucoxanthin-induced G(0)/G(1) arrest was associated with a marked decrease in the protein expressions of phosphorylated-Rb (retinoblastoma protein), cyclin D (1 and 2) and cyclin-dependent kinase (CDK) 4 and up-regulation of the protein levels of p15(INK4B) and p27(KiP1). Fucoxanthin-induced apoptosis was accompanied with the down-regulation of the protein levels of Bcl-xL, an inhibitor of apoptosis proteins (IAPs), resulting in a sequential activation of caspase-9, caspase-3, and PARP. Furthermore, the anti-tumor effect of fucoxanthin was assessed in vivo in Balb/c mice. Intraperitoneal administration of fucoxanthin significantly inhibited the growth of tumor mass in B16F10 cells implanted mice. (C) 2012 Elsevier B.V. All rights reserved.
ISSN
1382-6689
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3279
DOI
10.1016/j.etap.2012.10.002
Bibliographic Citation
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.35, no.1, pp.39 - 46, 2013
Publisher
ELSEVIER
Subject
CYCLE ARREST; CDK INHIBITORS; APOPTOSIS; INDUCTION; CANCER; PROTEIN; PROLIFERATION; ACTIVATION; MECHANISMS; EXPRESSION
Keywords
Fucoxanthin; Melanoma cell lines (B16F10 cells); Cell arrest; Apoptosis; p27(Kip1); Bcl-xL
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse