Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Kim, Kil-Nam | - |
dc.contributor.author | Ahn, Ginnae | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Kang, Sung-Myung | - |
dc.contributor.author | Kang, Min-Cheol | - |
dc.contributor.author | Yang, Hye-Mi | - |
dc.contributor.author | Kim, Daekyung | - |
dc.contributor.author | Roh, Seong Woon | - |
dc.contributor.author | Kim, Se-Kwon | - |
dc.contributor.author | Jeon, Byong-Tae | - |
dc.contributor.author | Park, Pyo-Jam | - |
dc.contributor.author | Jung, Won-Kyo | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.date.accessioned | 2020-04-20T05:55:26Z | - |
dc.date.available | 2020-04-20T05:55:26Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.issn | 1382-6689 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/3279 | - |
dc.description.abstract | The present study was designed to evaluate the molecular mechanisms of fucoxanthin against melanoma cell lines (B16F10 cells). Fucoxanthin reduced the proliferation of B16F10 cells in a dose-dependent manner accompanied by the induction of cell cycle arrest during the G(0)/G(1) phase and apoptosis. Fucoxanthin-induced G(0)/G(1) arrest was associated with a marked decrease in the protein expressions of phosphorylated-Rb (retinoblastoma protein), cyclin D (1 and 2) and cyclin-dependent kinase (CDK) 4 and up-regulation of the protein levels of p15(INK4B) and p27(KiP1). Fucoxanthin-induced apoptosis was accompanied with the down-regulation of the protein levels of Bcl-xL, an inhibitor of apoptosis proteins (IAPs), resulting in a sequential activation of caspase-9, caspase-3, and PARP. Furthermore, the anti-tumor effect of fucoxanthin was assessed in vivo in Balb/c mice. Intraperitoneal administration of fucoxanthin significantly inhibited the growth of tumor mass in B16F10 cells implanted mice. (C) 2012 Elsevier B.V. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.subject | CYCLE ARREST | - |
dc.subject | CDK INHIBITORS | - |
dc.subject | APOPTOSIS | - |
dc.subject | INDUCTION | - |
dc.subject | CANCER | - |
dc.subject | PROTEIN | - |
dc.subject | PROLIFERATION | - |
dc.subject | ACTIVATION | - |
dc.subject | MECHANISMS | - |
dc.subject | EXPRESSION | - |
dc.title | Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells | - |
dc.type | Article | - |
dc.citation.endPage | 46 | - |
dc.citation.startPage | 39 | - |
dc.citation.title | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.35, no.1, pp.39 - 46 | - |
dc.identifier.doi | 10.1016/j.etap.2012.10.002 | - |
dc.identifier.scopusid | 2-s2.0-84870809834 | - |
dc.identifier.wosid | 000314262300005 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | CDK INHIBITORS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Fucoxanthin | - |
dc.subject.keywordAuthor | Melanoma cell lines (B16F10 cells) | - |
dc.subject.keywordAuthor | Cell arrest | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | p27(Kip1) | - |
dc.subject.keywordAuthor | Bcl-xL | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |