New antimicrobial compounds from a marine-derived Bacillus sp. SCIE SCOPUS
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- Title
- New antimicrobial compounds from a marine-derived Bacillus sp.
- KIOST Author(s)
- Lee, Min Ah(이민아); Lee, Hyi Seung(이희승); Lee, Jong Seok(이종석); Lee, Yeon Ju(이연주); Shin, Hee Jae(신희재)
- Alternative Author(s)
- TAREQ; 김지혜; 이민아; 이희승; 이종석; 이연주; 신희재
- Publication Year
- 2013-02
- Abstract
- In the course of our ongoing research for antimicrobial agents, we isolated five new compounds, three 24-membered macrolactones, macrolactins X-Z (1-3) and two hydroxy unsaturated fatty acids, linieodolides A (5) and B (6), together with a known metabolite, macrolactinic acid (4), from the culture broth of a marine Bacillus sp. The structures of these metabolites were determined on the basis of their spectroscopic data interpretation. Their absolute configurations were addressed by modified Mosher's method and literature data review. Compounds 1-6 showed moderate to potent inhibitory activities (8 similar to 128 mu g ml(-1)) against selected pathogenic microorganisms. The Journal of Antibiotics (2013) 66, 89-95; doi:10.1038/ja.2012.102; published online 5 December 2012
- ISSN
- 0021-8820
- Bibliographic Citation
- JOURNAL OF ANTIBIOTICS, v.66, no.2, pp.89 - 95, 2013
- Publisher
- JAPAN ANTIBIOTICS RESEARCH ASSOC
- Subject
- ANTIBACTERIAL ACTIVITY; FATTY-ACIDS; MACROLACTINS; LACTONES
- Keywords
- antimicrobials; linieodolide; macrolactins; marine microorganisms
- Type
- Article
- Language
- English
- Document Type
- Article
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