New antimicrobial compounds from a marine-derived Bacillus sp.

Abstract

In the course of our ongoing research for antimicrobial agents, we isolated five new compounds, three 24-membered macrolactones, macrolactins X-Z (1-3) and two hydroxy unsaturated fatty acids, linieodolides A (5) and B (6), together with a known metabolite, macrolactinic acid (4), from the culture broth of a marine Bacillus sp. The structures of these metabolites were determined on the basis of their spectroscopic data interpretation. Their absolute configurations were addressed by modified Mosher's method and literature data review. Compounds 1-6 showed moderate to potent inhibitory activities (8 similar to 128 mu g ml(-1)) against selected pathogenic microorganisms. The Journal of Antibiotics (2013) 66, 89-95; doi:10.1038/ja.2012.102; published online 5 December 2012