The effect of cilostazol on the expression of matrix metalloproteinase-1 and type I procollagen in ultraviolet-irradiated human dermal fibroblasts
SCIE
SCOPUS
Cited 14 time in
WEB OF SCIENCE
Cited 15 time in
Scopus
-
Title
- The effect of cilostazol on the expression of matrix metalloproteinase-1 and type I procollagen in ultraviolet-irradiated human dermal fibroblasts
-
Author(s)
- Yu, Byeng Chul; Lee, Dae-Sung; Bae, Sang Mo; Jung, Won-Kyo; Chun, Jin Ho; Urm, Sang Hwa; Lee, Da-Young; Heo, Soo-Jin; Park, Sae-Gwang; Seo, Su-Kil; Yang, Jae Wook; Choi, Jung Sik; Park, Won Sun; Choi, Il-Whan
- KIOST Author(s)
- Heo, Soo Jin(허수진)
-
Alternative Author(s)
- 허수진
-
Publication Year
- 2013-03-12
-
Abstract
- Aim: Cilostazol is a selective inhibitor of type III phosphodiesterase that inhibits platelet aggregation. Cilostazol is a useful vasodilator, antithrombotic, and cardiotonic agent. Ultraviolet B (UVB) irradiation increases the production of matrix metalloproteinase-1 (MMP-1) during skin photoaging. The UVB-induced increase of MMP-1 results in connective tissue damage, and the skin becomes wrinkled and aged. Here, we investigated the capacity of cilostazol to inhibit MMP-1 expression in UVB-irradiated human dermal fibroblasts. Main methods: Cultured human dermal fibroblasts were irradiated with UVB, followed by the addition of cilostazol to the culture medium. Key findings: Post-treatment with cilostazol attenuated UVB-induced production of MMP-1 and prevented the reduction of type I procollagen. Cilostazol inhibited UVB irradiation-induced phosphorylation of the mitogen-activated protein kinase (MAPK) signaling molecules Jun-N-terminal kinase (JNK) and p38 kinase, as well as activator protein-1 (AP-1) in dermal fibroblasts. Significance: Overall, these results demonstrate that cilostazol regulates UVB-induced MMP-1 expression and type I procollagen synthesis by inhibiting MAPK signaling and AP-1 activity. Therefore, we suggest that cilostazol may be useful for the prevention and treatment of skin photodamage caused by UVB-irradiation. (C) 2013 Elsevier Inc. All rights reserved.
-
ISSN
- 0024-3205
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3208
-
DOI
- 10.1016/j.lfs.2012.12.011
-
Bibliographic Citation
- LIFE SCIENCES, v.92, no.4-5, pp.282 - 288, 2013
-
Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
-
Subject
- HUMAN SKIN FIBROBLASTS; ACTIVATED PROTEIN-KINASES; COLLAGENASE ACTIVATION; OXIDATIVE STRESS; BETA-CAROTENE; NADPH OXIDASE; TGF-BETA; UVA; INHIBITION; CELLS
-
Keywords
- Human dermal fibroblasts; Ultraviolet B; Cilostazol; Matrix metalloproteinase-1; Type I procollagen
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.