The effect of cilostazol on the expression of matrix metalloproteinase-1 and type I procollagen in ultraviolet-irradiated human dermal fibroblasts SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Yu, Byeng Chul | - |
dc.contributor.author | Lee, Dae-Sung | - |
dc.contributor.author | Bae, Sang Mo | - |
dc.contributor.author | Jung, Won-Kyo | - |
dc.contributor.author | Chun, Jin Ho | - |
dc.contributor.author | Urm, Sang Hwa | - |
dc.contributor.author | Lee, Da-Young | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Park, Sae-Gwang | - |
dc.contributor.author | Seo, Su-Kil | - |
dc.contributor.author | Yang, Jae Wook | - |
dc.contributor.author | Choi, Jung Sik | - |
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Choi, Il-Whan | - |
dc.date.accessioned | 2020-04-20T05:52:34Z | - |
dc.date.available | 2020-04-20T05:52:34Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2013-03-12 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/3208 | - |
dc.description.abstract | Aim: Cilostazol is a selective inhibitor of type III phosphodiesterase that inhibits platelet aggregation. Cilostazol is a useful vasodilator, antithrombotic, and cardiotonic agent. Ultraviolet B (UVB) irradiation increases the production of matrix metalloproteinase-1 (MMP-1) during skin photoaging. The UVB-induced increase of MMP-1 results in connective tissue damage, and the skin becomes wrinkled and aged. Here, we investigated the capacity of cilostazol to inhibit MMP-1 expression in UVB-irradiated human dermal fibroblasts. Main methods: Cultured human dermal fibroblasts were irradiated with UVB, followed by the addition of cilostazol to the culture medium. Key findings: Post-treatment with cilostazol attenuated UVB-induced production of MMP-1 and prevented the reduction of type I procollagen. Cilostazol inhibited UVB irradiation-induced phosphorylation of the mitogen-activated protein kinase (MAPK) signaling molecules Jun-N-terminal kinase (JNK) and p38 kinase, as well as activator protein-1 (AP-1) in dermal fibroblasts. Significance: Overall, these results demonstrate that cilostazol regulates UVB-induced MMP-1 expression and type I procollagen synthesis by inhibiting MAPK signaling and AP-1 activity. Therefore, we suggest that cilostazol may be useful for the prevention and treatment of skin photodamage caused by UVB-irradiation. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | HUMAN SKIN FIBROBLASTS | - |
dc.subject | ACTIVATED PROTEIN-KINASES | - |
dc.subject | COLLAGENASE ACTIVATION | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | BETA-CAROTENE | - |
dc.subject | NADPH OXIDASE | - |
dc.subject | TGF-BETA | - |
dc.subject | UVA | - |
dc.subject | INHIBITION | - |
dc.subject | CELLS | - |
dc.title | The effect of cilostazol on the expression of matrix metalloproteinase-1 and type I procollagen in ultraviolet-irradiated human dermal fibroblasts | - |
dc.type | Article | - |
dc.citation.endPage | 288 | - |
dc.citation.startPage | 282 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 92 | - |
dc.citation.number | 4-5 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.92, no.4-5, pp.282 - 288 | - |
dc.identifier.doi | 10.1016/j.lfs.2012.12.011 | - |
dc.identifier.scopusid | 2-s2.0-84873738085 | - |
dc.identifier.wosid | 000315479100005 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN SKIN FIBROBLASTS | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASES | - |
dc.subject.keywordPlus | COLLAGENASE ACTIVATION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BETA-CAROTENE | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | UVA | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Human dermal fibroblasts | - |
dc.subject.keywordAuthor | Ultraviolet B | - |
dc.subject.keywordAuthor | Cilostazol | - |
dc.subject.keywordAuthor | Matrix metalloproteinase-1 | - |
dc.subject.keywordAuthor | Type I procollagen | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |