Pulchranin A, isolated from the Far-Eastern marine sponge, Monanchora pulchra: the first marine non-peptide inhibitor of TRPV-1 channels SCIE SCOPUS

Cited 23 time in WEB OF SCIENCE Cited 22 time in Scopus
Title
Pulchranin A, isolated from the Far-Eastern marine sponge, Monanchora pulchra: the first marine non-peptide inhibitor of TRPV-1 channels
Author(s)
Guzii, Alla G.; Makarieva, Tatyana N.; Korolkova, Yuliya V.; Andreev, Yaroslav A.; Mosharova, Irina V.; Tabakmaher, Ksenya M.; Denisenko, Vladimir A.; Dmitrenok, Pavel S.; Ogurtsova, Ekaterina K.; Antonov, Alexandr S.; Lee, Hyi-Seung; Grishin, Eugene V.
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2013-03-06
Abstract
A new marine guanidine-containing compound, pulchranin A (1) was isolated from the marine sponge Monanchora pulchra. Its structure was elucidated by detailed NMR and MS analyses. The Mosher's method did not allow determination of the absolute configuration of the carbinol center in 1, but after conversion of 1 into the bis-MTPA esters of 1,3-diol 2, the same method was successfully used to solve the problem. Compound 1 was active as an inhibitor of the TRPV1 receptor with an EC50 value of 41.2 mu M. (C) 2012 Elsevier Ltd. All rights reserved.
ISSN
0040-4039
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3206
DOI
10.1016/j.tetlet.2012.12.099
Bibliographic Citation
TETRAHEDRON LETTERS, v.54, no.10, pp.1247 - 1250, 2013
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
POLYPEPTIDE INHIBITOR; GUANIDINE ALKALOIDS; MALYNGAMIDES; RECEPTOR
Keywords
Guanidine alkaloids; Absolute configuration; Sponge; Monanchora pulchra; TRPV1 channel; Inhibitor
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse