Pulchranin A, isolated from the Far-Eastern marine sponge, Monanchora pulchra: the first marine non-peptide inhibitor of TRPV-1 channels SCIE SCOPUS

DC Field Value Language
dc.contributor.author Guzii, Alla G. -
dc.contributor.author Makarieva, Tatyana N. -
dc.contributor.author Korolkova, Yuliya V. -
dc.contributor.author Andreev, Yaroslav A. -
dc.contributor.author Mosharova, Irina V. -
dc.contributor.author Tabakmaher, Ksenya M. -
dc.contributor.author Denisenko, Vladimir A. -
dc.contributor.author Dmitrenok, Pavel S. -
dc.contributor.author Ogurtsova, Ekaterina K. -
dc.contributor.author Antonov, Alexandr S. -
dc.contributor.author Lee, Hyi-Seung -
dc.contributor.author Grishin, Eugene V. -
dc.date.accessioned 2020-04-20T05:52:17Z -
dc.date.available 2020-04-20T05:52:17Z -
dc.date.created 2020-01-28 -
dc.date.issued 2013-03-06 -
dc.identifier.issn 0040-4039 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/3206 -
dc.description.abstract A new marine guanidine-containing compound, pulchranin A (1) was isolated from the marine sponge Monanchora pulchra. Its structure was elucidated by detailed NMR and MS analyses. The Mosher's method did not allow determination of the absolute configuration of the carbinol center in 1, but after conversion of 1 into the bis-MTPA esters of 1,3-diol 2, the same method was successfully used to solve the problem. Compound 1 was active as an inhibitor of the TRPV1 receptor with an EC50 value of 41.2 mu M. (C) 2012 Elsevier Ltd. All rights reserved. -
dc.description.uri 1 -
dc.language English -
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD -
dc.subject POLYPEPTIDE INHIBITOR -
dc.subject GUANIDINE ALKALOIDS -
dc.subject MALYNGAMIDES -
dc.subject RECEPTOR -
dc.title Pulchranin A, isolated from the Far-Eastern marine sponge, Monanchora pulchra: the first marine non-peptide inhibitor of TRPV-1 channels -
dc.type Article -
dc.citation.endPage 1250 -
dc.citation.startPage 1247 -
dc.citation.title TETRAHEDRON LETTERS -
dc.citation.volume 54 -
dc.citation.number 10 -
dc.identifier.bibliographicCitation TETRAHEDRON LETTERS, v.54, no.10, pp.1247 - 1250 -
dc.identifier.doi 10.1016/j.tetlet.2012.12.099 -
dc.identifier.scopusid 2-s2.0-84873127993 -
dc.identifier.wosid 000315321600018 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus POLYPEPTIDE INHIBITOR -
dc.subject.keywordPlus GUANIDINE ALKALOIDS -
dc.subject.keywordPlus MALYNGAMIDES -
dc.subject.keywordPlus RECEPTOR -
dc.subject.keywordAuthor Guanidine alkaloids -
dc.subject.keywordAuthor Absolute configuration -
dc.subject.keywordAuthor Sponge -
dc.subject.keywordAuthor Monanchora pulchra -
dc.subject.keywordAuthor TRPV1 channel -
dc.subject.keywordAuthor Inhibitor -
dc.relation.journalWebOfScienceCategory Chemistry, Organic -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Chemistry -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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