해양성 스트렙토마이세스에서 분리한 메틸피리딘류의 신규 항암물질
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정성윤 | - |
dc.contributor.author | 신희재 | - |
dc.contributor.author | 김태식 | - |
dc.contributor.author | 이희승 | - |
dc.date.accessioned | 2020-07-17T09:30:45Z | - |
dc.date.available | 2020-07-17T09:30:45Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2005-04-18 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/31558 | - |
dc.description.abstract | In the course of our screening program of bioactive marine natural products, we isolated a marine Actinomycete Streptomyces sp. from deep-sea sediments. This strain exhibited potent cytotoxic activity against human leukemia cell line(K-562). This strain was grown in modified Bennett's medium at 32C on a rotary shaker for 7 days. The cytotoxic compound was found in the culture broth but not in the cells. Bioassay-guided fractionations by solvent partitioning and purification with a reversed-phase HPLC gave a pure cytotoxic compound. Based upon the results of combined spectral analyses, the structure of this compound was determined to be a new methylpyridine derivative. This compound exhibited significant cytotoxic activity against human leukemia cell line (K-562). | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 대한약학회 | - |
dc.relation.isPartOf | Proceedings of the convention of the pharmaceutical society of Korea | - |
dc.title | 해양성 스트렙토마이세스에서 분리한 메틸피리딘류의 신규 항암물질 | - |
dc.title.alternative | A New Cytotoxic Compound of the Methylpyridine Class from a Marine-derived Streptomyces sp. | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 269 | - |
dc.citation.startPage | 268 | - |
dc.citation.title | Proceedings of the convention of the pharmaceutical society of Korea | - |
dc.contributor.alternativeName | 정성윤 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.contributor.alternativeName | 김태식 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.identifier.bibliographicCitation | Proceedings of the convention of the pharmaceutical society of Korea, pp.268 - 269 | - |
dc.description.journalClass | 2 | - |