해양성 스트렙토마이세스에서 분리한 메틸피리딘류의 신규 항암물질

Title
해양성 스트렙토마이세스에서 분리한 메틸피리딘류의 신규 항암물질
Alternative Title
A New Cytotoxic Compound of the Methylpyridine Class from a Marine-derived Streptomyces sp.
Author(s)
정성윤; 신희재; 김태식; 이희승
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hyi Seung(이희승)
Alternative Author(s)
정성윤; 신희재; 김태식; 이희승
Publication Year
2005-04-18
Abstract
In the course of our screening program of bioactive marine natural products, we isolated a marine Actinomycete Streptomyces sp. from deep-sea sediments. This strain exhibited potent cytotoxic activity against human leukemia cell line(K-562). This strain was grown in modified Bennett's medium at 32C on a rotary shaker for 7 days. The cytotoxic compound was found in the culture broth but not in the cells. Bioassay-guided fractionations by solvent partitioning and purification with a reversed-phase HPLC gave a pure cytotoxic compound. Based upon the results of combined spectral analyses, the structure of this compound was determined to be a new methylpyridine derivative. This compound exhibited significant cytotoxic activity against human leukemia cell line (K-562).
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/31558
Bibliographic Citation
Proceedings of the convention of the pharmaceutical society of Korea, pp.268 - 269, 2005
Publisher
대한약학회
Type
Conference
Language
English
Publisher
대한약학회
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