2-aminogluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF-a production induced by enteric LPS

Title
2-aminogluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF-a production induced by enteric LPS
Author(s)
이희승; G.J. Boons
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2005-10-21
Abstract
The naturally occurring LPS from Rhizobium sin-1 can prevent the induction of TNF-α induced by enteric LPS. The proximal saccharide moiety of R. sin-1 lipid A can exist in two forms as a 2-aminogluconolactone or 2-aminogluconate. As it is unknown which of these forms is responsible for the antagonistic properties of R. sin-1 lipid A, a new derivative, which contains a methyl ether at the C-5 hydroxyl was prepared by a highly convergent approach using a key disaccharide building block and its inflammatory properties studied. The novel synthetic compound lacks proinflammatory properties as indicated by an absence of TNF-α protein production. This compound was, however, able to antagonize the production of TNF-α induced by enteric LPS, indicating that the 2-aminogluconate form of R. sin-1 lipid A is responsible for its biological properties.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/31272
Bibliographic Citation
대한화학회 96회 학술발표회, pp.366, 2005
Publisher
대한화학회
Type
Conference
Language
English
Publisher
대한화학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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