2-aminogluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF-a production induced by enteric LPS
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Title
- 2-aminogluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF-a production induced by enteric LPS
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Author(s)
- 이희승; G.J. Boons
- KIOST Author(s)
- Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이희승
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Publication Year
- 2005-10-21
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Abstract
- The naturally occurring LPS from Rhizobium sin-1 can prevent the induction of TNF-α induced by enteric LPS. The proximal saccharide moiety of R. sin-1 lipid A can exist in two forms as a 2-aminogluconolactone or 2-aminogluconate. As it is unknown which of these forms is responsible for the antagonistic properties of R. sin-1 lipid A, a new derivative, which contains a methyl ether at the C-5 hydroxyl was prepared by a highly convergent approach using a key disaccharide building block and its inflammatory properties studied. The novel synthetic compound lacks proinflammatory properties as indicated by an absence of TNF-α protein production. This compound was, however, able to antagonize the production of TNF-α induced by enteric LPS, indicating that the 2-aminogluconate form of R. sin-1 lipid A is responsible for its biological properties.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/31272
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Bibliographic Citation
- 대한화학회 96회 학술발표회, pp.366, 2005
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Publisher
- 대한화학회
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Type
- Conference
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Language
- English
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