2-aminogluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF-a production induced by enteric LPS
DC Field | Value | Language |
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dc.contributor.author | 이희승 | - |
dc.contributor.author | G.J. Boons | - |
dc.date.accessioned | 2020-07-17T07:51:06Z | - |
dc.date.available | 2020-07-17T07:51:06Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2005-10-21 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/31272 | - |
dc.description.abstract | The naturally occurring LPS from Rhizobium sin-1 can prevent the induction of TNF-α induced by enteric LPS. The proximal saccharide moiety of R. sin-1 lipid A can exist in two forms as a 2-aminogluconolactone or 2-aminogluconate. As it is unknown which of these forms is responsible for the antagonistic properties of R. sin-1 lipid A, a new derivative, which contains a methyl ether at the C-5 hydroxyl was prepared by a highly convergent approach using a key disaccharide building block and its inflammatory properties studied. The novel synthetic compound lacks proinflammatory properties as indicated by an absence of TNF-α protein production. This compound was, however, able to antagonize the production of TNF-α induced by enteric LPS, indicating that the 2-aminogluconate form of R. sin-1 lipid A is responsible for its biological properties. | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 대한화학회 | - |
dc.relation.isPartOf | 대한화학회 96회 학술발표회 | - |
dc.title | 2-aminogluconate isomer of Rhizobium sin-1 lipid A can antagonize TNF-a production induced by enteric LPS | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 366 | - |
dc.citation.startPage | 366 | - |
dc.citation.title | 대한화학회 96회 학술발표회 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.identifier.bibliographicCitation | 대한화학회 96회 학술발표회, pp.366 | - |
dc.description.journalClass | 2 | - |