Novel Angiogenesis Inhibitor from Streptomyces sp. Isolated from a Marine Sponge

Abstract

Angiogenesis, the process of new blood vessel formation, is crucial for the development and progression of pathophysiological changes associated with a variety of disorders, including various cancers, tumor metastases, and retinopathies. Malignant angiogenesis plays a critical role in several fatal diseases including cancer, vascular insufficiency, diabetic retinopathy, and rheumatoid arthritis by a normal delivering mechanism of oxygen and nutrients to cell and tissue. Because tumor angiogenesis caused by angiogenic inducers is the most critical factor in the growth of solid tumors, as well as their invasion and metastasis, early control of angiogenesis may be a promising therapeutic strategy for the related diseases. As part of our ongoing program to develop the biomedical potential of marine microorganisms, we isolated a new angiogenesis inhibiotr from the fermentation broth of a marine Streptomyces sp. The isolation, structure determination, and anti-angiogenesis activity of the new compound from marine actinomycete will be presented.