Novel Monofunctional Histidinol Phosphatase of the DDDD Superfamily of Phosphohydrolases

Title
Novel Monofunctional Histidinol Phosphatase of the DDDD Superfamily of Phosphohydrolases
Author(s)
이현숙; 조요나; 이정현; 강성균
KIOST Author(s)
Lee, Hyun Sook(이현숙)Lee, Jung Hyun(이정현)Kang, Sung Gyun(강성균)
Publication Year
2008-05-16
Abstract
Histidinol Phosphatase (HPase) is a committed enzyme in the eighth step of histidine biosynthesis pathway. Genes for all enzymes of the pathway except HPase are found in a genome of the hyperthermophilic archaeon Thermococcus onnurineus NA1. In this study, a gene (TON_0887) to encode a putative HAD superfamily hydrolase was identified as the best candidate for the missing HPase gene by the analysis of his gene cluster. TON_0887 displayed three or four order of magnitude preference for histidinol phosphate to AMP, fructose 6-phosphate or phosphoserine. Based on the genome analysis of Thermococcus kodakaraensis and Phyrococcus furiosus, two orthologues of TON_0887 are anticipated to represent the missing HPases. Our work provides the first assessment of a monofunctional HPase belong to the DDDD superfamily of phosphohydrolases.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/30039
Bibliographic Citation
한국미생물학회, pp.209, 2008
Publisher
한국미생물학회 2008 춘계 국제학술대회
Type
Conference
Language
English
Publisher
한국미생물학회 2008 춘계 국제학술대회
Related Researcher
Research Interests

marine biotechnology,molecular microbiology,해양생명공학,분자미생물학

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