Heterologous microarray hybridization used to differential gene expression profiling in Benzo[a]pyrene exposed marine medaka

Title
Heterologous microarray hybridization used to differential gene expression profiling in Benzo[a]pyrene exposed marine medaka
Author(s)
원효경; Woo S; Park H; 염승식
KIOST Author(s)
Yum, Seungshic(염승식)
Publication Year
2009-09-22
Abstract
Differential gene expression profiling was carried out in the hepatic tissue of marine medaka fish, Oryzias javanicus, after exposure to benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), by heterologous hybridization using a medaka cDNA microarray. Forty kinds of differentially expressed candidate genes, with 24 induced and 16 repressed in their gene expressions (P < 0.01), which were associated with cell cycle, development, endocrine/reproduction, immune, metabolism, nucleic acid/protein binding, signal transduction, and non-categorized. The presumptive physiological changes induced by B[a]P exposure could be deduced after considering the biological function of each gene candidates. The identified genes could be used as molecular biomarkers for biological responses to B[a]P contamination in an aquatic environment.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/29341
Bibliographic Citation
The Joint International Symposium of 5th International Conference on Toxicogenomics (ICT) and 2nd Toxicogenomics Integrated Environmental Science (TIES), pp.69, 2009
Publisher
Molecular and Cellular Toxicology
Type
Conference
Language
English
Publisher
Molecular and Cellular Toxicology
Related Researcher
Research Interests

Marine Genomics,Environmental Genomics,Novel biomaterials,해양생물유전체,생태환경유전체,바이오신소재

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