Anti-inflammatory activity of marine algae in lipopolysaccharide-stimulated RAW 264.7 macrophage

Title
Anti-inflammatory activity of marine algae in lipopolysaccharide-stimulated RAW 264.7 macrophage
Author(s)
허수진; Weon-Jong Yoon; Kil-Nam Kim; Sung-Myung Kang; 강도형; You-Jin Jeon
KIOST Author(s)
Heo, Soo Jin(허수진)Kang, Do Hyung(강도형)
Publication Year
2010-03-02
Abstract
Fucoxanthin, is considered to be one of major active compound of marine algae, has been shown to exhibit antioxidant, anti-proliferative, anti-obesity, and antitumor activities. In this study, therefore, we have examined the anti-inflammatory effect of fucoxanthin isolated from brown algae, Myagropsis myagroides on lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.Fucoxanthin significantly inhibited the nitric oxide (NO) production, but slightly reduced the prostaglandin E2 (PGE2) production in RAW 264.7 macrophages. The inducible nitric oxide synthase (iNOS) and cyclooxigenase 2 (COX-2) protein expressions were inhibited by addition of fucoxanthin. RT-PCR analysis indicated that the iNOS and COX-2 mRNA expression were suppressed by addition of fucoxanthin. Moreover, the release of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), and the mRNA expression levels of these cytokines were reduced by addition of fucoxanthin in a dosedependent manner. Hence, these results suggest that the use of fucoxanthin may be a useful therapeutic approach for the various inflammatorydiseases.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/29064
Bibliographic Citation
World Aquaculture Society, pp.940, 2010
Publisher
World Aquaculture Society
Type
Conference
Language
English
Publisher
World Aquaculture Society
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