Anti-inflammatory activity of marine algae in lipopolysaccharide-stimulated RAW 264.7 macrophage

DC Field Value Language
dc.contributor.author 허수진 -
dc.contributor.author Weon-Jong Yoon -
dc.contributor.author Kil-Nam Kim -
dc.contributor.author Sung-Myung Kang -
dc.contributor.author 강도형 -
dc.contributor.author You-Jin Jeon -
dc.date.accessioned 2020-07-16T20:50:53Z -
dc.date.available 2020-07-16T20:50:53Z -
dc.date.created 2020-02-11 -
dc.date.issued 2010-03-02 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/29064 -
dc.description.abstract Fucoxanthin, is considered to be one of major active compound of marine algae, has been shown to exhibit antioxidant, anti-proliferative, anti-obesity, and antitumor activities. In this study, therefore, we have examined the anti-inflammatory effect of fucoxanthin isolated from brown algae, Myagropsis myagroides on lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.Fucoxanthin significantly inhibited the nitric oxide (NO) production, but slightly reduced the prostaglandin E2 (PGE2) production in RAW 264.7 macrophages. The inducible nitric oxide synthase (iNOS) and cyclooxigenase 2 (COX-2) protein expressions were inhibited by addition of fucoxanthin. RT-PCR analysis indicated that the iNOS and COX-2 mRNA expression were suppressed by addition of fucoxanthin. Moreover, the release of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), and the mRNA expression levels of these cytokines were reduced by addition of fucoxanthin in a dosedependent manner. Hence, these results suggest that the use of fucoxanthin may be a useful therapeutic approach for the various inflammatorydiseases. -
dc.description.uri 1 -
dc.language English -
dc.publisher World Aquaculture Society -
dc.relation.isPartOf World Aquaculture Society -
dc.title Anti-inflammatory activity of marine algae in lipopolysaccharide-stimulated RAW 264.7 macrophage -
dc.type Conference -
dc.citation.conferencePlace US -
dc.citation.endPage 940 -
dc.citation.startPage 940 -
dc.citation.title World Aquaculture Society -
dc.contributor.alternativeName 허수진 -
dc.contributor.alternativeName 강도형 -
dc.identifier.bibliographicCitation World Aquaculture Society, pp.940 -
dc.description.journalClass 1 -
Appears in Collections:
Jeju Research Institute > Jeju Bio Research Center > 2. Conference Papers
Jeju Research Institute > Tropical & Subtropical Research Center > 2. Conference Papers
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse