Molecular cloning and characterization of SOCS-2 from Manila clam Ruditapes philippinarum SCIE SCOPUS
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- Title
- Molecular cloning and characterization of SOCS-2 from Manila clam Ruditapes philippinarum
- KIOST Author(s)
- Lee, Young Deuk(이영득); Oh, Chul Hong(오철홍); Kang, Do Hyung(강도형)
- Alternative Author(s)
- 이영득; 오철홍; 강도형
- Publication Year
- 2014-02
- Abstract
- Suppressor of cytokine signaling (SOCS) family members are key regulators of immunological homeostasis. In this study, we have discovered the SOCS-2 member from Manila clam Ruditapes philippinarum and further analyzed its immune responses against lipopolysaccharide (LPS) and polyinosinic:polycytidylic acid (poly I:C). Amino acid sequence of RpSOCS-2 consists of cytokine inducible SRC homology 2 (SH2) and SOCS box domains similar to vertebrate SOCS counterparts. It has the highest amino acid identity (41%) with Pacific oyster (Crassostrea gigas) SOCS-2 and showed close evolutional relationship with disk abalone (Haliotis discus discus) SOCS-2. Tissue specific expression results showed that RpSOCS-2 was constitutively expressed in all examined tissues with the highest level in gill tissue of un-challenged clams. RpSOCS-2 mRNA expression was up-regulated by LPS and poly I:C challenge in gills. Discovery of RpSOCS-2 homologue and expression analysis would support for understanding evolutional relationships and their role in innate immune responses in mollusks, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
- ISSN
- 1050-4648
- Bibliographic Citation
- FISH & SHELLFISH IMMUNOLOGY, v.36, no.2, pp.453 - 458, 2014
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Subject
- SEQUENCE ALIGNMENT; SUPPRESSOR; EXPRESSION; IDENTIFICATION; INSIGHTS
- Keywords
- Manila clam; Ruditapes philippinarum; Suppressor of cytokine signaling (SOCS); LPS; poly I:C
- Type
- Article
- Language
- English
- Document Type
- Article
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