Molecular cloning and characterization of SOCS-2 from Manila clam Ruditapes philippinarum SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Lee, Youngdeuk | - |
dc.contributor.author | Choi, Jin-young | - |
dc.contributor.author | Oh, Chulhong | - |
dc.contributor.author | Kang, Do-Hyoung | - |
dc.contributor.author | Choi, Su-young | - |
dc.contributor.author | Heo, Gang-Joon | - |
dc.contributor.author | Lee, Jehee | - |
dc.contributor.author | De Zoysa, Mahanama | - |
dc.date.accessioned | 2020-04-20T04:56:52Z | - |
dc.date.available | 2020-04-20T04:56:52Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2871 | - |
dc.description.abstract | Suppressor of cytokine signaling (SOCS) family members are key regulators of immunological homeostasis. In this study, we have discovered the SOCS-2 member from Manila clam Ruditapes philippinarum and further analyzed its immune responses against lipopolysaccharide (LPS) and polyinosinic:polycytidylic acid (poly I:C). Amino acid sequence of RpSOCS-2 consists of cytokine inducible SRC homology 2 (SH2) and SOCS box domains similar to vertebrate SOCS counterparts. It has the highest amino acid identity (41%) with Pacific oyster (Crassostrea gigas) SOCS-2 and showed close evolutional relationship with disk abalone (Haliotis discus discus) SOCS-2. Tissue specific expression results showed that RpSOCS-2 was constitutively expressed in all examined tissues with the highest level in gill tissue of un-challenged clams. RpSOCS-2 mRNA expression was up-regulated by LPS and poly I:C challenge in gills. Discovery of RpSOCS-2 homologue and expression analysis would support for understanding evolutional relationships and their role in innate immune responses in mollusks, respectively. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | SEQUENCE ALIGNMENT | - |
dc.subject | SUPPRESSOR | - |
dc.subject | EXPRESSION | - |
dc.subject | IDENTIFICATION | - |
dc.subject | INSIGHTS | - |
dc.title | Molecular cloning and characterization of SOCS-2 from Manila clam Ruditapes philippinarum | - |
dc.type | Article | - |
dc.citation.endPage | 458 | - |
dc.citation.startPage | 453 | - |
dc.citation.title | FISH & SHELLFISH IMMUNOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 2 | - |
dc.contributor.alternativeName | 이영득 | - |
dc.contributor.alternativeName | 오철홍 | - |
dc.contributor.alternativeName | 강도형 | - |
dc.identifier.bibliographicCitation | FISH & SHELLFISH IMMUNOLOGY, v.36, no.2, pp.453 - 458 | - |
dc.identifier.doi | 10.1016/j.fsi.2013.12.012 | - |
dc.identifier.scopusid | 2-s2.0-84893169329 | - |
dc.identifier.wosid | 000332052100015 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SEQUENCE ALIGNMENT | - |
dc.subject.keywordPlus | SUPPRESSOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordAuthor | Manila clam | - |
dc.subject.keywordAuthor | Ruditapes philippinarum | - |
dc.subject.keywordAuthor | Suppressor of cytokine signaling (SOCS) | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | poly I:C | - |
dc.relation.journalWebOfScienceCategory | Fisheries | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Fisheries | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |