Isolation of cytotoxic sesterterpenoid suvanine from a tropical marine sponge

Title
Isolation of cytotoxic sesterterpenoid suvanine from a tropical marine sponge
Author(s)
이정우; 이희승; 이연주
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)
Publication Year
2010-10-14
Abstract
In the course our research for the discovery of bioactive substances from marine sponges collected from Chuuk, Federated States of Micronesia, we have encountered a sponge of which the extract exhibited significant cytotoxity against human leukemia cell line. A careful investigation of chemical composition revealed that the extract contains large amount of suvanine, a sesterterpene sulfate reported to have inhibitory activity against thrombin and trypsin. The IC50 value of suvanine was 31.6 μg/mL, which suggests that the cytotoxicity of the extract results from suvanine. Other sesterterpenoids expected to have structures analogous to suvanine were also obtained and their structures are under investigation.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/28708
Bibliographic Citation
대한화학회 제106회 총회 및 학술발표회, pp.2, 2010
Publisher
대한화학회
Type
Conference
Language
English
Publisher
대한화학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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