Non-cytotoxic Antifungal Agents: Isolation and Structures of Gageopeptides A-D from a Bacillus Strain 109GGC020
SCIE
SCOPUS
Cited 23 time in
WEB OF SCIENCE
Cited 29 time in
Scopus
-
Title
- Non-cytotoxic Antifungal Agents: Isolation and Structures of Gageopeptides A-D from a Bacillus Strain 109GGC020
-
Author(s)
- Tareq, Fakir Shahidullah; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Hasan, Choudhury M.; Islam, Md. Tofazzal; Shin, Hee Jae
- KIOST Author(s)
- Lee, Min Ah(이민아); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주); Lee, Jong Seok(이종석); Shin, Hee Jae(신희재)
-
Alternative Author(s)
- TAREQ; 이민아; 이희승; 이연주; 이종석; 신희재
-
Publication Year
- 2014-06-18
-
Abstract
- Antifungal resistance and toxicity problems of conventional fungicides highlighted the requirement of search for new safe antifungal agents. To comply with the requirement, we discovered four new non-cytotoxic lipopeptides, gageopeptides A D, 1-4, from a marine-derived bacterium Bacillus subtilis. The structures and stereochemistry of gageopeptides were determined by NMR data analysis and chemical means. Gageopeptides exhibited significant antifungal activities against pathogenic fungi Rhizoctonia solani, Botrytis cinerea, and Colletotrichum acutatum with minimum inhibitory concentration (MIC) values of 0.02-0.06 mu M. In addition, these lipopeptides showed significant motility inhibition and lytic activities against zoospores of the late blight pathogen Phytophthora capsici. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04-0.08 mu M. However, gageopeptides A-D did not exhibit any cytotoxicity (GI(50) > 25 mu M) against cancer cell lines in sulforhodamine B (SRB), 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), and WST-1 ((4-[3-4-iodophenyl]-2-(4-nitrophenyl)-2H-5-tetrazolio)-1,3-benzene disulfonate)) assays, demonstrating that these compounds could be promising candidates for the development of non-cytotoxic antifungal agents.
-
ISSN
- 0021-8561
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2788
-
DOI
- 10.1021/jf502436r
-
Bibliographic Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.24, pp.5565 - 5572, 2014
-
Publisher
- AMER CHEMICAL SOC
-
Subject
- ANTIMICROBIAL LINEAR LIPOPEPTIDES; DAMPING-OFF; SUBTILIS; SURFACTIN; DISEASE; GROWTH; PLANTS; ASSAY
-
Keywords
- Bacillus subtilis; gageopeptides; antifungal agents; non-cytotoxicity
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.