Non-cytotoxic Antifungal Agents: Isolation and Structures of Gageopeptides A-D from a Bacillus Strain 109GGC020 SCIE SCOPUS

Cited 22 time in WEB OF SCIENCE Cited 21 time in Scopus
Title
Non-cytotoxic Antifungal Agents: Isolation and Structures of Gageopeptides A-D from a Bacillus Strain 109GGC020
Author(s)
Tareq, Fakir Shahidullah; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Hasan, Choudhury M.; Islam, Md. Tofazzal; Shin, Hee Jae
KIOST Author(s)
Lee, Min Ah(이민아)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)
Alternative Author(s)
TAREQ; 이민아; 이희승; 이연주; 이종석; 신희재
Publication Year
2014-06-18
Abstract
Antifungal resistance and toxicity problems of conventional fungicides highlighted the requirement of search for new safe antifungal agents. To comply with the requirement, we discovered four new non-cytotoxic lipopeptides, gageopeptides A D, 1-4, from a marine-derived bacterium Bacillus subtilis. The structures and stereochemistry of gageopeptides were determined by NMR data analysis and chemical means. Gageopeptides exhibited significant antifungal activities against pathogenic fungi Rhizoctonia solani, Botrytis cinerea, and Colletotrichum acutatum with minimum inhibitory concentration (MIC) values of 0.02-0.06 mu M. In addition, these lipopeptides showed significant motility inhibition and lytic activities against zoospores of the late blight pathogen Phytophthora capsici. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04-0.08 mu M. However, gageopeptides A-D did not exhibit any cytotoxicity (GI(50) > 25 mu M) against cancer cell lines in sulforhodamine B (SRB), 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), and WST-1 ((4-[3-4-iodophenyl]-2-(4-nitrophenyl)-2H-5-tetrazolio)-1,3-benzene disulfonate)) assays, demonstrating that these compounds could be promising candidates for the development of non-cytotoxic antifungal agents.
ISSN
0021-8561
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2788
DOI
10.1021/jf502436r
Bibliographic Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.24, pp.5565 - 5572, 2014
Publisher
AMER CHEMICAL SOC
Subject
ANTIMICROBIAL LINEAR LIPOPEPTIDES; DAMPING-OFF; SUBTILIS; SURFACTIN; DISEASE; GROWTH; PLANTS; ASSAY
Keywords
Bacillus subtilis; gageopeptides; antifungal agents; non-cytotoxicity
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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