Non-cytotoxic Antifungal Agents: Isolation and Structures of Gageopeptides A-D from a Bacillus Strain 109GGC020 SCIE SCOPUS

DC Field Value Language Tareq, Fakir Shahidullah - Lee, Min Ah - Lee, Hyi-Seung - Lee, Yeon-Ju - Lee, Jong Seok - Hasan, Choudhury M. - Islam, Md. Tofazzal - Shin, Hee Jae - 2020-04-20T04:40:29Z - 2020-04-20T04:40:29Z - 2020-01-28 - 2014-06-18 -
dc.identifier.issn 0021-8561 -
dc.identifier.uri -
dc.description.abstract Antifungal resistance and toxicity problems of conventional fungicides highlighted the requirement of search for new safe antifungal agents. To comply with the requirement, we discovered four new non-cytotoxic lipopeptides, gageopeptides A D, 1-4, from a marine-derived bacterium Bacillus subtilis. The structures and stereochemistry of gageopeptides were determined by NMR data analysis and chemical means. Gageopeptides exhibited significant antifungal activities against pathogenic fungi Rhizoctonia solani, Botrytis cinerea, and Colletotrichum acutatum with minimum inhibitory concentration (MIC) values of 0.02-0.06 mu M. In addition, these lipopeptides showed significant motility inhibition and lytic activities against zoospores of the late blight pathogen Phytophthora capsici. These compounds also showed potent antimicrobial activity against Gram positive and Gram negative bacteria with MIC values of 0.04-0.08 mu M. However, gageopeptides A-D did not exhibit any cytotoxicity (GI(50) > 25 mu M) against cancer cell lines in sulforhodamine B (SRB), 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), and WST-1 ((4-[3-4-iodophenyl]-2-(4-nitrophenyl)-2H-5-tetrazolio)-1,3-benzene disulfonate)) assays, demonstrating that these compounds could be promising candidates for the development of non-cytotoxic antifungal agents. -
dc.description.uri 1 -
dc.language English -
dc.publisher AMER CHEMICAL SOC -
dc.subject DAMPING-OFF -
dc.subject SUBTILIS -
dc.subject SURFACTIN -
dc.subject DISEASE -
dc.subject GROWTH -
dc.subject PLANTS -
dc.subject ASSAY -
dc.title Non-cytotoxic Antifungal Agents: Isolation and Structures of Gageopeptides A-D from a Bacillus Strain 109GGC020 -
dc.type Article -
dc.citation.endPage 5572 -
dc.citation.startPage 5565 -
dc.citation.volume 62 -
dc.citation.number 24 -
dc.contributor.alternativeName TAREQ -
dc.contributor.alternativeName 이민아 -
dc.contributor.alternativeName 이희승 -
dc.contributor.alternativeName 이연주 -
dc.contributor.alternativeName 이종석 -
dc.contributor.alternativeName 신희재 -
dc.identifier.bibliographicCitation JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.24, pp.5565 - 5572 -
dc.identifier.doi 10.1021/jf502436r -
dc.identifier.scopusid 2-s2.0-84902674916 -
dc.identifier.wosid 000337720100020 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus DAMPING-OFF -
dc.subject.keywordPlus SUBTILIS -
dc.subject.keywordPlus SURFACTIN -
dc.subject.keywordPlus DISEASE -
dc.subject.keywordPlus GROWTH -
dc.subject.keywordPlus PLANTS -
dc.subject.keywordPlus ASSAY -
dc.subject.keywordAuthor Bacillus subtilis -
dc.subject.keywordAuthor gageopeptides -
dc.subject.keywordAuthor antifungal agents -
dc.subject.keywordAuthor non-cytotoxicity -
dc.relation.journalWebOfScienceCategory Agriculture, Multidisciplinary -
dc.relation.journalWebOfScienceCategory Chemistry, Applied -
dc.relation.journalWebOfScienceCategory Food Science & Technology -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Agriculture -
dc.relation.journalResearchArea Chemistry -
dc.relation.journalResearchArea Food Science & Technology -
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Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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