Isolation and biological activities of psammaplysin analogs from the tropical marine sponge

Abstract

Psammaplysins, known to exhibit potent antimalarial activities, are nonterpenoid secondary metabolites derived from bromotyrosine. In the course of our search for bioactive substances from the tropical marine sponges, eight psammaplysin analogs have been isolated. They exhibited moderate to high inhibition activities against the growth of cancer cell lines. analogs have been isolated. They exhibited moderate to high inhibition activities against the growth of cancer cell lines.