Bioactive secondary metabolites from Coscinoderma sp. and Stylissa flabeliformis

Abstract

Marin natural product chemistry is based on a study regarding the structural elucidations of extracted substances from marine organisms. More than 18,000 novel secondary metabolites have been isolated from various marine organisms such as sponges, ascidians, algae and microorganisms. Research on the marine natural products possesses tremendous potentials on both academic and industrial aspects of biosciences.In the course of our research for the bioactive secondary metabolites from marine organisms, we encountered with the marine sponge Coscinoderma sp. from Chuuk, Faderated states of Micronesia, which is well known to cause paralysis through a skin contact among the natives of Micronesia. Studies on the chemical investigation of the marine sponge Coscinoderma sp. led to the isolation of three new sesterterpenoids together with previously reported six compounds. All the isolated compounds were subjected to the enzyme-based assay against isocitrate lyase and Na+/K+-ATPase and the results suggested that suvanins with two diffrerent counter-cation have high inhibitory activity against Na+/K+-ATPase.h as sponges, ascidians, algae and microorganisms. Research on the marine natural products possesses tremendous potentials on both academic and industrial aspects of biosciences.In the course of our research for the bioactive secondary metabolites from marine organisms, we encountered with the marine sponge Coscinoderma sp. from Chuuk, Faderated states of Micronesia, which is well known to cause paralysis through a skin contact among the natives of Micronesia. Studies on the chemical investigation of the marine sponge Coscinoderma sp. led to the isolation of three new sesterterpenoids together with previously reported six compounds. All the isolated compounds were subjected to the enzyme-based assay against isocitrate lyase and Na+/K+-ATPase and the results suggested that suvanins with two diffrerent counter-cation have high inhibito