INNATE IMMUNE AND BIOTRANSFORMATION RESPONSES BY FEEDING EXPOSURE TO IRANIAN HEAVY CRUDE OIL ON ROCKFISH (SEBASTES SCHLEGELI)

Title
INNATE IMMUNE AND BIOTRANSFORMATION RESPONSES BY FEEDING EXPOSURE TO IRANIAN HEAVY CRUDE OIL ON ROCKFISH (SEBASTES SCHLEGELI)
Author(s)
김하나; 정지현; 채영선; 심원준; 박찬일
KIOST Author(s)
Jung, Jee Hyun(정지현)Shim, Won Joon(심원준)
Publication Year
2013-05-08
Abstract
In the study,w e exposedju veniler ockfishto spilledc rudeo il (lranianH eavyC rudeO il IHCOi ngelatin capsulesf)r om the Hebei spirit oil spill by feeding.T he effectso n multiplef ishhepatodetoxificatioenn zymes( CytochromeP 4501Aa nd GST)a nd the expressionle vel of theimmuner esponseg enes,in cludingin terleukin-1be(tlaL -1p)g, ranulocyleco lony-stimulatifnagc tor(G-CSFa)n dC athepsiLn (CTSLw),e re measuredin the liver,s pleena nd kidneyT. heo il-fedf ishh adsignificantlhyi gherc oncentrationosf biliaryf luorescenmt etaboliteasn d CYPlAe xpressiodnu ringthe initials tagea fter exposure( L2*48h r after exposuret)h an those in the livera nd kidneyo f thecontrogl roup.S imilarlyth, e highesmt RNAe xpressiolne velso f lL-1p andG -CSwFe red etectedin thelivera t the earlys tageso f exposure(1 2h r aftere xposure)F.o llowinegx posuret,h e levelso f lSG15and G-CSFm RNAr emainedh igha t 120h r aftert reatmenti n the liverb ut the levelso f lL-l p andCTSLg raduallyd ecreasetdo an expressiolne vele qualt o or lesst hant he controlg roup.O ur datasuggestth at the innatei mmunea ndh epatodetoxificatiroens ponseisn oil-fedf ishw erei nduceda tthe initials tageo f exposureto the IHCOa t the samet ime but severailm mune-relategde nesdecreasetdo lesst hant hat of the controlg roupa ftert he initials tageo f responseT.h ec umulativemortalitiews erec alculateedv erydapy ost-bactericahl allengeA. significanint creasien fishm ortalitywas also observedi n oil exposureg roup comparedt o the sham group.T herefore,im munedisturbanceins fishe xposedto IHCOm aya llowt he pathogensin, cludintgh e infectiouds iseasesto,moree asilya ffectf ish.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27084
Bibliographic Citation
17th Pollutant Responses in Marine Organisms, pp.366, 2013
Publisher
17th PRIMO
Type
Conference
Language
English
Publisher
17th PRIMO
Related Researcher
Research Interests

Microplastic pollution,Persistent Organic Pollutants,Oil Pollution,미세플라스틱 오염,잔류성 유기오염물질,유류오염

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