INNATE IMMUNE AND BIOTRANSFORMATION RESPONSES BY FEEDING EXPOSURE TO IRANIAN HEAVY CRUDE OIL ON ROCKFISH (SEBASTES SCHLEGELI)
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Title
- INNATE IMMUNE AND BIOTRANSFORMATION RESPONSES BY FEEDING EXPOSURE TO IRANIAN HEAVY CRUDE OIL ON ROCKFISH (SEBASTES SCHLEGELI)
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Author(s)
- 김하나; 정지현; 채영선; 심원준; 박찬일
- KIOST Author(s)
- Jung, Jee Hyun(정지현); Shim, Won Joon(심원준)
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Alternative Author(s)
- 김하나; 정지현; 채영선; 심원준
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Publication Year
- 2013-05-08
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Abstract
- In the study,w e exposedju veniler ockfishto spilledc rudeo il (lranianH eavyC rudeO il IHCOi ngelatin capsulesf)r om the Hebei spirit oil spill by feeding.T he effectso n multiplef ishhepatodetoxificatioenn zymes( CytochromeP 4501Aa nd GST)a nd the expressionle vel of theimmuner esponseg enes,in cludingin terleukin-1be(tlaL -1p)g, ranulocyleco lony-stimulatifnagc tor(G-CSFa)n dC athepsiLn (CTSLw),e re measuredin the liver,s pleena nd kidneyT. heo il-fedf ishh adsignificantlhyi gherc oncentrationosf biliaryf luorescenmt etaboliteasn d CYPlAe xpressiodnu ringthe initials tagea fter exposure( L2*48h r after exposuret)h an those in the livera nd kidneyo f thecontrogl roup.S imilarlyth, e highesmt RNAe xpressiolne velso f lL-1p andG -CSwFe red etectedin thelivera t the earlys tageso f exposure(1 2h r aftere xposure)F.o llowinegx posuret,h e levelso f lSG15and G-CSFm RNAr emainedh igha t 120h r aftert reatmenti n the liverb ut the levelso f lL-l p andCTSLg raduallyd ecreasetdo an expressiolne vele qualt o or lesst hant he controlg roup.O ur datasuggestth at the innatei mmunea ndh epatodetoxificatiroens ponseisn oil-fedf ishw erei nduceda tthe initials tageo f exposureto the IHCOa t the samet ime but severailm mune-relategde nesdecreasetdo lesst hant hat of the controlg roupa ftert he initials tageo f responseT.h ec umulativemortalitiews erec alculateedv erydapy ost-bactericahl allengeA. significanint creasien fishm ortalitywas also observedi n oil exposureg roup comparedt o the sham group.T herefore,im munedisturbanceins fishe xposedto IHCOm aya llowt he pathogensin, cludintgh e infectiouds iseasesto,moree asilya ffectf ish.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/27084
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Bibliographic Citation
- 17th Pollutant Responses in Marine Organisms, pp.366, 2013
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Publisher
- 17th PRIMO
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Type
- Conference
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Language
- English
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