Effect of Curcumin on Lipid Metabolism in Rats Fed High and Fat High Cholesterol Diet

Title
Effect of Curcumin on Lipid Metabolism in Rats Fed High and Fat High Cholesterol Diet
Author(s)
김민선; 예보람; 오철홍; 강도형; 허수진
KIOST Author(s)
Oh, Chulhong(오철홍)Kang, Do-Hyung(강도형)Heo, Soo Jin(허수진)
Publication Year
2013-10-30
Abstract
The purpose of the present study was also investigate the effects of curcumin on lipid metabolism in rats fed high fat‧ high cholesterol diet. Sprague-Dawley male rats weighing 120±10 g were randomly assigned to normal diet group (N), high fat‧ high cholesterol diet group (HF), high fat‧ high cholesterol diet with 0.05% (CPA) and 0.10% (CPB) curcumin powder supplemented group. The hepatic TG contents in CPA and CPB groups were significantly decreased than that of HF. The hepatic total-cholesterol contents in HF group were significantly increased compared to the N group. The fecal triglyceride contents of CPA and CPB groups were increased than that of HF group. The fecal total-cholesterol contents of CPA and CPB groups were increased than that of HF group. The serum total bile acid contents of CPA and CPB groups were significantly increased compared to HF group. The serum leptin contents of CPA and CPB groups were significantly decreased compared to HF group. The hepatic UDP-GT activity of CPA and CPB groups were significantly increased compared to the HF group. Therefore, this study suggested that the curcumin may have powerful health benefits by the modulation of physiological functions such as lipid metabolism. high fat‧ high cholesterol diet group (HF), high fat‧ high cholesterol diet with 0.05% (CPA) and 0.10% (CPB) curcumin powder supplemented group. The hepatic TG contents in CPA and CPB groups were significantly decreased than that of HF. The hepatic total-cholesterol contents in HF group were significantly increased compared to the N group. The fecal triglyceride contents of CPA and CPB groups were increased than that of HF group. The fecal total-cholesterol contents of CPA and CPB groups were increased than that of HF group. The serum total bile acid contents of CPA and CPB groups were significantly increased compared to HF group. The serum leptin contents of CPA and CPB groups were significantly decreased compared to HF group. The hepatic UDP-GT activity of CPA and CPB groups were significantly increased compared to the HF group. Therefore, this study suggested that the curcumin may have powerful health benefits by the modulation of physiological functions such as lipid metabolism.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/26634
Bibliographic Citation
2013 한국생물공학회, pp.307, 2013
Publisher
한국생물공학회
Type
Conference
Language
English
Publisher
한국생물공학회
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