Effect of Curcumin on Lipid Metabolism in Rats Fed High and Fat High Cholesterol Diet

Abstract

The purpose of the present study was also investigate the effects of curcumin on lipid metabolism in rats fed high fat&#8231 high cholesterol diet. Sprague-Dawley male rats weighing 120±10 g were randomly assigned to normal diet group (N), high fat&#8231 high cholesterol diet group (HF), high fat&#8231 high cholesterol diet with 0.05% (CPA) and 0.10% (CPB) curcumin powder supplemented group. The hepatic TG contents in CPA and CPB groups were significantly decreased than that of HF. The hepatic total-cholesterol contents in HF group were significantly increased compared to the N group. The fecal triglyceride contents of CPA and CPB groups were increased than that of HF group. The fecal total-cholesterol contents of CPA and CPB groups were increased than that of HF group. The serum total bile acid contents of CPA and CPB groups were significantly increased compared to HF group. The serum leptin contents of CPA and CPB groups were significantly decreased compared to HF group. The hepatic UDP-GT activity of CPA and CPB groups were significantly increased compared to the HF group. Therefore, this study suggested that the curcumin may have powerful health benefits by the modulation of physiological functions such as lipid metabolism. high fat&#8231 high cholesterol diet group (HF), high fat&#8231 high cholesterol diet with 0.05% (CPA) and 0.10% (CPB) curcumin powder supplemented group. The hepatic TG contents in CPA and CPB groups were significantly decreased than that of HF. The hepatic total-cholesterol contents in HF group were significantly increased compared to the N group. The fecal triglyceride contents of CPA and CPB groups were increased than that of HF group. The fecal total-cholesterol contents of CPA and CPB groups were increased than that of HF group. The serum total bile acid contents of CPA and CPB groups were significantly increased compared to HF group. The serum leptin contents of CPA and CPB groups were significantly decreased compared to HF group. The hepatic UDP-GT activity of CPA and CPB groups were significantly increased compared to the HF group. Therefore, this study suggested that the curcumin may have powerful health benefits by the modulation of physiological functions such as lipid metabolism.