고래의 게놈에서 hypoxia-inducible factor binding site의 예측과 target gene에 대한 분석 OTHER

Title
고래의 게놈에서 hypoxia-inducible factor binding site의 예측과 target gene에 대한 분석
Alternative Title
Prediction of hypoxia-inducible factor binding site in whale genome and analysis of target genes regulated by predicted sites
Author(s)
임형순; 이재학
KIOST Author(s)
Yim, Hyung Soon(임형순)
Publication Year
2015
Abstract
Whales are marine mammals that are fully adapted to aquatic environment. Whales breathe by lungs so they require adaptive system to low oxygen concentration (hypoxia) while deep and prolonged diving. However, the study for the molecular mechanism underlying cetacean adaptation to hypoxia has been limited. Hypoxia-inducible factor (HIF) is the central transcription factor that regulates hypoxia-related gene expression. Here we identified HIF-binding sites in whale genome by phylogenetic footprinting and analyzed HIF-target genes to understand how whales cope with hypoxia. By comparison with the HIF-target genes of terrestrial mammals, it was suggested that whales may retain unique adaptation mechanisms to hypoxia.hanism underlying cetacean adaptation to hypoxia has been limited. Hypoxia-inducible factor (HIF) is the central transcription factor that regulates hypoxia-related gene expression. Here we identified HIF-binding sites in whale genome by phylogenetic footprinting and analyzed HIF-target genes to understand how whales cope with hypoxia. By comparison with the HIF-target genes of terrestrial mammals, it was suggested that whales may retain unique adaptation mechanisms to hypoxia.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2623
Bibliographic Citation
Journal of Mairne Bioscience and Biotechnology, v.7, no.2, pp.35 - 41, 2015
Type
Article
Language
Korean
Related Researcher
Research Interests

marine genomics,biochemistry,molecular cell biology,해양 유전체,생화학,세포분자 생물학

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