Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma
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Title
- Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma
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Author(s)
- Kwak, Tae Won; Shin, Hee Jae; Jeong, Young-Il; Han, Myoung-Eun; Oh, Sae-Ock; Kim, Hyun-Jung; Kim, Do Hyung; Kang, Dae Hwan
- KIOST Author(s)
- Shin, Hee Jae(신희재)
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Alternative Author(s)
- 신희재
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Publication Year
- 2015
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Abstract
- Background: The aim of this study is to investigate the anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma. Methods: The anticancer activity of streptochlorin was evaluated in vitro in various cholangiocarcinoma cell lines for apoptosis, proliferation, invasiveness, and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1 cholangiocarcinoma cells using a BALB/c nude mouse model to study the systemic antimetastatic efficacy of streptochlorin 5 mg/kg at 8 weeks. The antitumor efficacy of subcutaneously injected streptochlorin was also assessed using a solid tumor xenograft model of SNU478 cells for 22 days in the BALB/c nude mouse. Results: Streptochlorin inhibited growth and secretion of vascular endothelial growth factor by cholangiocarcinoma cells in a dose-dependent manner and induced apoptosis in vitro. In addition, streptochlorin effectively inhibited invasion and migration of cholangiocarcinoma cells. Secretion of vascular endothelial growth factor and activity of matrix metalloproteinase-9 in cholangiocarcinoma cells were also suppressed by treatment with streptochlorin. Streptochlorin effectively regulated metastasis of HuCC-T1 cells in a mouse model of liver metastasis. In a tumor xenograft study using SNU478 cells, streptochlorin significantly inhibited tumor growth without changes in body weight when compared with the control. Conclusion: These results reveal that streptochlorin is a promising chemotherapeutic agent to the treatment of cholangiocarcinoma.
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ISSN
- 1177-8881
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2614
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DOI
- 10.2147/DDDT.S80205
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Bibliographic Citation
- DRUG DESIGN DEVELOPMENT AND THERAPY, v.9, pp.2201 - 2214, 2015
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Publisher
- DOVE MEDICAL PRESS LTD
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Keywords
- streptochlorin; cholangiocarcinoma; chemotherapeutic agent; invasion; metastasis
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Type
- Article
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Language
- English
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Document Type
- Article
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