Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Kwak, Tae Won | - |
dc.contributor.author | Shin, Hee Jae | - |
dc.contributor.author | Jeong, Young-Il | - |
dc.contributor.author | Han, Myoung-Eun | - |
dc.contributor.author | Oh, Sae-Ock | - |
dc.contributor.author | Kim, Hyun-Jung | - |
dc.contributor.author | Kim, Do Hyung | - |
dc.contributor.author | Kang, Dae Hwan | - |
dc.date.accessioned | 2020-04-20T03:55:31Z | - |
dc.date.available | 2020-04-20T03:55:31Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1177-8881 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2614 | - |
dc.description.abstract | Background: The aim of this study is to investigate the anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma. Methods: The anticancer activity of streptochlorin was evaluated in vitro in various cholangiocarcinoma cell lines for apoptosis, proliferation, invasiveness, and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1 cholangiocarcinoma cells using a BALB/c nude mouse model to study the systemic antimetastatic efficacy of streptochlorin 5 mg/kg at 8 weeks. The antitumor efficacy of subcutaneously injected streptochlorin was also assessed using a solid tumor xenograft model of SNU478 cells for 22 days in the BALB/c nude mouse. Results: Streptochlorin inhibited growth and secretion of vascular endothelial growth factor by cholangiocarcinoma cells in a dose-dependent manner and induced apoptosis in vitro. In addition, streptochlorin effectively inhibited invasion and migration of cholangiocarcinoma cells. Secretion of vascular endothelial growth factor and activity of matrix metalloproteinase-9 in cholangiocarcinoma cells were also suppressed by treatment with streptochlorin. Streptochlorin effectively regulated metastasis of HuCC-T1 cells in a mouse model of liver metastasis. In a tumor xenograft study using SNU478 cells, streptochlorin significantly inhibited tumor growth without changes in body weight when compared with the control. Conclusion: These results reveal that streptochlorin is a promising chemotherapeutic agent to the treatment of cholangiocarcinoma. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma | - |
dc.type | Article | - |
dc.citation.endPage | 2214 | - |
dc.citation.startPage | 2201 | - |
dc.citation.title | DRUG DESIGN DEVELOPMENT AND THERAPY | - |
dc.citation.volume | 9 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.identifier.bibliographicCitation | DRUG DESIGN DEVELOPMENT AND THERAPY, v.9, pp.2201 - 2214 | - |
dc.identifier.doi | 10.2147/DDDT.S80205 | - |
dc.identifier.scopusid | 2-s2.0-84929179182 | - |
dc.identifier.wosid | 000352947000001 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | CISPLATIN PLUS GEMCITABINE | - |
dc.subject.keywordPlus | STREPTOMYCES SP | - |
dc.subject.keywordPlus | PERINEURAL INVASION | - |
dc.subject.keywordPlus | TARGETED THERAPY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | streptochlorin | - |
dc.subject.keywordAuthor | cholangiocarcinoma | - |
dc.subject.keywordAuthor | chemotherapeutic agent | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | metastasis | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |