Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma SCIE SCOPUS

DC Field Value Language Kwak, Tae Won - Shin, Hee Jae - Jeong, Young-Il - Han, Myoung-Eun - Oh, Sae-Ock - Kim, Hyun-Jung - Kim, Do Hyung - Kang, Dae Hwan - 2020-04-20T03:55:31Z - 2020-04-20T03:55:31Z - 2020-01-28 - 2015 -
dc.identifier.issn 1177-8881 -
dc.identifier.uri -
dc.description.abstract Background: The aim of this study is to investigate the anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma. Methods: The anticancer activity of streptochlorin was evaluated in vitro in various cholangiocarcinoma cell lines for apoptosis, proliferation, invasiveness, and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1 cholangiocarcinoma cells using a BALB/c nude mouse model to study the systemic antimetastatic efficacy of streptochlorin 5 mg/kg at 8 weeks. The antitumor efficacy of subcutaneously injected streptochlorin was also assessed using a solid tumor xenograft model of SNU478 cells for 22 days in the BALB/c nude mouse. Results: Streptochlorin inhibited growth and secretion of vascular endothelial growth factor by cholangiocarcinoma cells in a dose-dependent manner and induced apoptosis in vitro. In addition, streptochlorin effectively inhibited invasion and migration of cholangiocarcinoma cells. Secretion of vascular endothelial growth factor and activity of matrix metalloproteinase-9 in cholangiocarcinoma cells were also suppressed by treatment with streptochlorin. Streptochlorin effectively regulated metastasis of HuCC-T1 cells in a mouse model of liver metastasis. In a tumor xenograft study using SNU478 cells, streptochlorin significantly inhibited tumor growth without changes in body weight when compared with the control. Conclusion: These results reveal that streptochlorin is a promising chemotherapeutic agent to the treatment of cholangiocarcinoma. -
dc.description.uri 1 -
dc.language English -
dc.title Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma -
dc.type Article -
dc.citation.endPage 2214 -
dc.citation.startPage 2201 -
dc.citation.volume 9 -
dc.identifier.bibliographicCitation DRUG DESIGN DEVELOPMENT AND THERAPY, v.9, pp.2201 - 2214 -
dc.identifier.doi 10.2147/DDDT.S80205 -
dc.identifier.scopusid 2-s2.0-84929179182 -
dc.identifier.wosid 000352947000001 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordPlus CISPLATIN PLUS GEMCITABINE -
dc.subject.keywordPlus STREPTOMYCES SP -
dc.subject.keywordPlus PERINEURAL INVASION -
dc.subject.keywordPlus TARGETED THERAPY -
dc.subject.keywordPlus DIAGNOSIS -
dc.subject.keywordPlus CANCER -
dc.subject.keywordPlus CLASSIFICATION -
dc.subject.keywordPlus PATHOGENESIS -
dc.subject.keywordPlus MANAGEMENT -
dc.subject.keywordPlus APOPTOSIS -
dc.subject.keywordAuthor streptochlorin -
dc.subject.keywordAuthor cholangiocarcinoma -
dc.subject.keywordAuthor chemotherapeutic agent -
dc.subject.keywordAuthor invasion -
dc.subject.keywordAuthor metastasis -
dc.relation.journalWebOfScienceCategory Chemistry, Medicinal -
dc.relation.journalWebOfScienceCategory Pharmacology & Pharmacy -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Pharmacology & Pharmacy -
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Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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