Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 9 time in Scopus
Title
Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma
Author(s)
Kwak, Tae Won; Shin, Hee Jae; Jeong, Young-Il; Han, Myoung-Eun; Oh, Sae-Ock; Kim, Hyun-Jung; Kim, Do Hyung; Kang, Dae Hwan
KIOST Author(s)
Shin, Hee Jae(신희재)
Publication Year
2015
Abstract
Background: The aim of this study is to investigate the anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma. Methods: The anticancer activity of streptochlorin was evaluated in vitro in various cholangiocarcinoma cell lines for apoptosis, proliferation, invasiveness, and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1 cholangiocarcinoma cells using a BALB/c nude mouse model to study the systemic antimetastatic efficacy of streptochlorin 5 mg/kg at 8 weeks. The antitumor efficacy of subcutaneously injected streptochlorin was also assessed using a solid tumor xenograft model of SNU478 cells for 22 days in the BALB/c nude mouse. Results: Streptochlorin inhibited growth and secretion of vascular endothelial growth factor by cholangiocarcinoma cells in a dose-dependent manner and induced apoptosis in vitro. In addition, streptochlorin effectively inhibited invasion and migration of cholangiocarcinoma cells. Secretion of vascular endothelial growth factor and activity of matrix metalloproteinase-9 in cholangiocarcinoma cells were also suppressed by treatment with streptochlorin. Streptochlorin effectively regulated metastasis of HuCC-T1 cells in a mouse model of liver metastasis. In a tumor xenograft study using SNU478 cells, streptochlorin significantly inhibited tumor growth without changes in body weight when compared with the control. Conclusion: These results reveal that streptochlorin is a promising chemotherapeutic agent to the treatment of cholangiocarcinoma.
ISSN
1177-8881
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2614
DOI
10.2147/DDDT.S80205
Bibliographic Citation
DRUG DESIGN DEVELOPMENT AND THERAPY, v.9, pp.2201 - 2214, 2015
Publisher
DOVE MEDICAL PRESS LTD
Keywords
streptochlorin; cholangiocarcinoma; chemotherapeutic agent; invasion; metastasis
Type
Article
Language
English
Document Type
Article
Publisher
DOVE MEDICAL PRESS LTD
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