Three Tetramic Acid Derivatives, Penicillenols A1, A2, and a New Penicillenol Analog from a Marine Fungus Penicillium citrinum

Abstract

Marine organisms have been received significant attention in various fields since they produce unique and novel chemical compounds. Especially, marine microbes are considered as a novel source for biologically and chemically active products. Although marine microbes have been studied to find new and unusual products, lots of microorganisms and their secondary metabolites still remain undiscovered under the ocean. The strain 1310CH-032 was isolated from a sponge collected in Chuuk island, Micronesia and identified as Penicillium citrinum. From this strain, three tetramic acid derivatives, penicillenols A1, A2, and a new penicillenol analog were isolated from the EtOAc extract of the culture broth (25L). The structures of the compounds were determined by using MS and 2D NMR analyses.. Although marine microbes have been studied to find new and unusual products, lots of microorganisms and their secondary metabolites still remain undiscovered under the ocean. The strain 1310CH-032 was isolated from a sponge collected in Chuuk island, Micronesia and identified as Penicillium citrinum. From this strain, three tetramic acid derivatives, penicillenols A1, A2, and a new penicillenol analog were isolated from the EtOAc extract of the culture broth (25L). The structures of the compounds were determined by using MS and 2D NMR analyses.