Insights into the Evolution of Longevity from the Bowhead Whale Genome SCIE SCOPUS

Cited 150 time in WEB OF SCIENCE Cited 154 time in Scopus
Title
Insights into the Evolution of Longevity from the Bowhead Whale Genome
Author(s)
Keane, Michael; Semeiks, Jeremy; Webb, Andrew E.; Li, Yang I.; Quesada, Victor; Craig, Thomas; Madsen, Lone Bruhn; van Dam, Sipko; Brawand, David; Marques, Patricia I.; Michalak, Pawel; Kang, Lin; Bhak, Jong; Yim, Hyung-Soon; Grishin, Nick V.; Nielsen, Nynne Hjort; Heide-Jorgensen, Mads Peter; Oziolor, Elias M.; Matson, Cole W.; Church, George M.; Stuart, Gary W.; Patton, John C.; George, J. Craig; Suydam, Robert; Larsen, Knud; Lopez-Otin, Carlos; O'Connell, Mary J.; Bickham, John W.; Thomsen, Bo; de Magalhaes, Joao Pedro
KIOST Author(s)
Yim, Hyung Soon(임형순)
Publication Year
2015-01-06
Abstract
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bow-head-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species.
ISSN
2211-1247
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2548
DOI
10.1016/j.celrep.2014.12.008
Bibliographic Citation
CELL REPORTS, v.10, no.1, pp.112 - 122, 2015
Publisher
CELL PRESS
Subject
BALAENA-MYSTICETUS; ADAPTIVE EVOLUTION; WEST GREENLAND; SEQUENCE; GENE; AGE; TRANSCRIPTOME; RESISTANCE; PIPELINE; BIOLOGY
Type
Article
Language
English
Document Type
Article
Publisher
CELL PRESS
Related Researcher
Research Interests

marine genomics,biochemistry,molecular cell biology,해양 유전체,생화학,세포분자 생물학

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