A Novel Mechanism of Reduction of Dimethyl Sulfoxide

Title
A Novel Mechanism of Reduction of Dimethyl Sulfoxide
Author(s)
최애란; 김민식; 강성균; 이현숙
KIOST Author(s)
Kang, Sung Gyun(강성균)Lee, Hyun Sook(이현숙)
Publication Year
2015-11-06
Abstract
To date, a variety of microbes are known to grow by respiration with dimethyl sulfoxide (DMSO) as an electron acceptor. Several bacteria, such as Escherichia coli and Rhodopseudomonas capsula, have been characterized on DMSO respiratory systems consisted of electron carriers and a terminal DMSO reductase. In this study, we presented that cysteine-cystine redox shuttle serves as an electron mediator for DMSO reduction. Our experimental results show that thioredoxin reductase-protein disulfide oxidoreductase redox couple has a potential suitable for catalyzing the reduction of cystine to cysteine, permitting recycle of cysteine. Based on this mechanism of growth stimulation by DMSO via a redox-regulating system and an extracellular electron mediator, DMSO reduction is proposed to function simply by disposing of excess reducing power rather than conserving energy.tems consisted of electron carriers and a terminal DMSO reductase. In this study, we presented that cysteine-cystine redox shuttle serves as an electron mediator for DMSO reduction. Our experimental results show that thioredoxin reductase-protein disulfide oxidoreductase redox couple has a potential suitable for catalyzing the reduction of cystine to cysteine, permitting recycle of cysteine. Based on this mechanism of growth stimulation by DMSO via a redox-regulating system and an extracellular electron mediator, DMSO reduction is proposed to function simply by disposing of excess reducing power rather than conserving energy.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/25111
Bibliographic Citation
2015 한국미생물학회연합 국제할술대회, pp.264, 2015
Publisher
한국미생물학회연합
Type
Conference
Language
English
Publisher
한국미생물학회연합
Related Researcher
Research Interests

Microbial biotechnology,Marine enzymes,미생물 활용,효소 개발

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