Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models SCIE SCOPUS

Cited 4 time in WEB OF SCIENCE Cited 5 time in Scopus
Title
Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models
Author(s)
Shim, Do-Wan; Shin, Hee Jae; Han, Ji-Won; Shin, Woo-Young; Sun, Xiao; Shim, Eun-Jeong; Kim, Tack-Joong; Kang, Tae-Bong; Lee, Kwang-Ho
Publication Year
2015-04
Abstract
Streptochlorin, a small compound derived from marine actinomycete, has been shown to have anti-angiogenic, anti-tumor, and anti-allergic activities. However, the anti-inflammatory effects and underlying mechanisms have not yet been reported. In the present study, we investigated the effect of streptochlorin on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. Streptochlorin attenuated the production of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1, and IL-6 in LPS-stimulated RAW264.7 cells through inhibition of the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon- (TRIF)-dependent signaling pathway. Furthermore, streptochlorin suppressed the infiltration of immune cells such as neutrophils into the lung and proinflammatory cytokine production such as IL-6 and TNF- in broncho-alveolar lavage fluid (BALF) in the LPS-induced acute lung injury (ALI) mouse model. Streptochlorin has potent anti-inflammatory effects through regulating TRIF-dependent signaling pathways, suggesting that streptochlorin may provide a valuable therapeutic strategy in treating various inflammatory diseases.
ISSN
1422-0067
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2509
DOI
10.3390/ijms16046902
Bibliographic Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.16, no.4, pp.6902 - 6910, 2015
Publisher
MDPI AG
Keywords
streptochlorin; LPS; anti-inflammation; TRIF; ALI
Type
Article
Language
English
Document Type
Article
Publisher
MDPI AG
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