Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models
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Title
- Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models
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Author(s)
- Shim, Do-Wan; Shin, Hee Jae; Han, Ji-Won; Shin, Woo-Young; Sun, Xiao; Shim, Eun-Jeong; Kim, Tack-Joong; Kang, Tae-Bong; Lee, Kwang-Ho
- KIOST Author(s)
- Shin, Hee Jae(신희재)
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Alternative Author(s)
- 신희재
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Publication Year
- 2015-04
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Abstract
- Streptochlorin, a small compound derived from marine actinomycete, has been shown to have anti-angiogenic, anti-tumor, and anti-allergic activities. However, the anti-inflammatory effects and underlying mechanisms have not yet been reported. In the present study, we investigated the effect of streptochlorin on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. Streptochlorin attenuated the production of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1, and IL-6 in LPS-stimulated RAW264.7 cells through inhibition of the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon- (TRIF)-dependent signaling pathway. Furthermore, streptochlorin suppressed the infiltration of immune cells such as neutrophils into the lung and proinflammatory cytokine production such as IL-6 and TNF- in broncho-alveolar lavage fluid (BALF) in the LPS-induced acute lung injury (ALI) mouse model. Streptochlorin has potent anti-inflammatory effects through regulating TRIF-dependent signaling pathways, suggesting that streptochlorin may provide a valuable therapeutic strategy in treating various inflammatory diseases.
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ISSN
- 1422-0067
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2509
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DOI
- 10.3390/ijms16046902
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Bibliographic Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.16, no.4, pp.6902 - 6910, 2015
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Publisher
- MDPI AG
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Keywords
- streptochlorin; LPS; anti-inflammation; TRIF; ALI
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Type
- Article
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Language
- English
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Document Type
- Article
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